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Lack of Association Between Depression and Subclinical Hypothyroidism in Adolescents Presenting for Routine Physical Examinations.

Background: There are conflicting results in the existing studies regarding the association between depression and subclinical hypothyroidism in adolescents. Subclinical hypothyroidism is defined as elevated thyroid stimulating hormone (TSH) levels above the reference range without signs or symptoms...

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Published in:Clinical Medicine Insights: Pediatrics pp. 1 - 6
Main Authors: Kumaratne, Mohan, Vigneron, Franck, Cisneros, Jasmine, Rajapakse, Vinodh
Format: research tables/charts Journal Article
Published: Sage Publications Inc. 1/27/2024
Online Access:View this record in EBSCOhost
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      dt: 1/27/2024
      pid: 20732
      pub: Sage Publications Inc.
      place: Thousand Oaks, California
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        10.1177/11795565231220503
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        atl: Lack of Association Between Depression and Subclinical Hypothyroidism in Adolescents Presenting for Routine Physical Examinations.
      aug:
        au:
          Kumaratne, Mohan
          Vigneron, Franck
          Cisneros, Jasmine
          Rajapakse, Vinodh
        affil: HB Pediatrics and Adolescent Medicine Clinic, Huntington Beach, CA, USA
      sug:
        subj:
          Depression In Adolescence
          Hypothyroidism In Adolescence
          Physical Examination
          COVID-19 Pandemic United States
          Mental Health
          Thyrotropin Blood
          Quantitative Studies
          Cross Sectional Studies
          United States
          Health Screening
          Questionnaires
          Human
          Male
          Correlational Studies
          Female
          Adolescence
          Reference Values
          Data Analysis Software
          Descriptive Statistics
          Adolescent: 13-18 years
          Male
          Female
      ab: Background: There are conflicting results in the existing studies regarding the association between depression and subclinical hypothyroidism in adolescents. Subclinical hypothyroidism is defined as elevated thyroid stimulating hormone (TSH) levels above the reference range without signs or symptoms of hypothyroidism. Objectives: The focus of this study is to determine whether there is any association between depression and subclinical hypothyroidism, (as defined by the serum TSH levels) in a population of healthy adolescents. Design: Quantitative-based cross-sectional study of a representative subset of the adolescent population. Methods: We carried out a cross-sectional study to determine the association between major depressive disorder (MDD) and subclinical hypothyroidism, in adolescents presenting for annual physical examinations during the peak period of the COVID-19 pandemic in the USA, a period deemed high for adolescent depression. All the adolescents were screened for depression by the PHQ-9 screening tool and had their TSH measured. Results: Of the 304 subjects analyzed, 179 (58.88%) were minimally or not depressed according to the Patient Health Questionnaire (PHQ-9) screening tool (mean PHQ 1.80 ± 1.49). 70 (23.03%) had mild depression (mean PHQ 6.59 ± 1.46), 50 (16.45%) had moderate depression (mean PHQ 13.70 ± 2.75), and 5 (1.64%) had severe depression (mean PHQ 21.40 ± 1.67). Mean TSH values were 1.93 ± 0.99, 1.77 ± 1.05, 2.10 ± 0.98, and 1.57 ± 0.32 mIU/L, respectively in the four groups. All values were within the recommended range of 0.50 to 4.30 mIU/L, without statistically significant inter-group differences. Conclusion: We conclude that there is no statistically significant association between depression and subclinical hypothyroidism, in a population of adolescents presenting for physical examinations, and if the screening for depression by the PHQ-9 tool indicates depression, a screening TSH test for subclinical hypothyroidism is not justified.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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