A Comprehensive Bioinformatic Analysis of RNA-seq Datasets Reveals a Differential and Variable Expression of Wildtype and Variant UGT1A Transcripts in Human Tissues and Their Deregulation in Cancers.

Simple Summary: UGT enzymes metabolize and detoxify numerous small molecules that are important in cancer, including carcinogens, endogenous growth regulators, and anticancer drugs. Alternatively spliced UGT transcripts can encode truncated proteins that inhibit canonical UGTs, thus reducing detoxif...

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Publicado en:	Cancers Vol. 16; no. 2; pp. 353 - 376
Autores principales:	Hu, Dong Gui, Marri, Shashikanth, Hulin, Julie-Ann, McKinnon, Ross A., Mackenzie, Peter I., Meech, Robyn
Formato:	research tables/charts Journal Article
Publicado:	MDPI Jan2024
Acceso en línea:	Ver este registro en EBSCOhost