A recombinant signalling‐selective activated protein C that lacks anticoagulant activity is efficacious and safe in cutaneous wound preclinical models.

Various preclinical and clinical studies have demonstrated the robust wound healing capacity of the natural anticoagulant activated protein C (APC). A bioengineered APC variant designated 3K3A‐APC retains APC's cytoprotective cell signalling actions with <10% anticoagulant activity. This study was a...

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Bibliographic Details

Published in:	Wound Repair & Regeneration Vol. 32; no. 1; pp. 90 - 104
Main Authors:	Zhao, Ruilong, Xue, Meilang, Lin, Haiyan, Smith, Margaret, Liang, Helena, Weiler, Hartmut, Griffin, John H., Jackson, Christopher J.
Format:	pictorial research tables/charts Journal Article
Published:	Wiley-Blackwell Jan/Feb2024
Online Access:	View this record in EBSCOhost