Idiopathic Granulomatous Mastitis.

Idiopathic granulomatous mastitis (IGM) is a rare, benign inflammatory disorder of the breast that is often underrecognized. The exact etiology and pathophysiology are unknown, but milk stasis is felt to play a role. Classically, this condition is noninfectious, but many cases are noted to be associ...

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Publicado en:Breast Journal pp. 1 - 10
Autores principales: Dilaveri, Christina, Degnim, Amy, Lee, Christine, DeSimone, Daniel, Moldoveanu, Dan, Ghosh, Karthik
Formato: review tables/charts Journal Article
Publicado: Wiley-Blackwell 1/25/2024
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 1/25/2024
      pid: 480
      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        10.1155/2024/6693720
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        atl: Idiopathic Granulomatous Mastitis.
      aug:
        au:
          Dilaveri, Christina
          Degnim, Amy
          Lee, Christine
          DeSimone, Daniel
          Moldoveanu, Dan
          Ghosh, Karthik
        affil: Mayo Clinic, Department of Medicine, Division of General Internal Medicine, Rochester, USA
      sug:
        subj:
          Mastitis Diagnosis
          Granuloma Diagnosis
          Mastitis Pathology
          Granuloma Pathology
          Disease Attributes
          Neoplasm Recurrence, Local
          Diagnosis, Differential
          Biopsy
          Methotrexate Therapeutic Use
          Azathioprine Therapeutic Use
          Mycophenolate Mofetil Therapeutic Use
          Bromocriptine Therapeutic Use
          Mastitis Drug Therapy
          Granuloma Drug Therapy
          Mastitis Etiology
          Granuloma Etiology
      ab: Idiopathic granulomatous mastitis (IGM) is a rare, benign inflammatory disorder of the breast that is often underrecognized. The exact etiology and pathophysiology are unknown, but milk stasis is felt to play a role. Classically, this condition is noninfectious, but many cases are noted to be associated with Corynebacterium species. Most patients affected are parous women with a mean age of 35, and many have breastfed within five years of diagnosis. Patients typically present with a painful mass and symptoms of inflammation, and these features can sometimes mimic breast cancer. Biopsy is needed to make a definitive diagnosis, and noncaseating granulomas are found on core biopsy. Many patients have a waxing and waning course over a period of six months to two years. Goal of treatment is to avoid surgery given poor wound healing, high risk of recurrence, and poor cosmetic outcomes. Medical treatment is preferred and includes observation, antibiotics, steroids, and immune modulators such as methotrexate. In more recent years, topical and intralesional steroids have become the treatment of choice, with similar outcomes to oral steroids.
      pubtype: Academic Journal
      doctype:
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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