The Influence of TNFRSF1B, PADI4, and miRNA 499 Gene Polymorphisms on Susceptibility and Responsiveness to TNF Inhibitors in Patients with Rheumatoid Arthritis.
Background & Objective: Rheumatoid arthritis (RA) is a systemic autoimmune disease that causes joint deterioration. Over the past decade, the primary approach to treat RA has relied on biological medications. Despite confirming the effectiveness of this therapy, patients have shown significant diver...
| Publicado en: | Journal of Advances in Medical & Biomedical Research Vol. 31; no. 147; pp. 381 - 391 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Zanjan University of Medical Sciences & Health Services
Jul/Aug2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175221099&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175221099 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 26766264 N5MJ jtl: Journal of Advances in Medical & Biomedical Research issn: 26766264 maglogo: N pubinfo: dt: Jul/Aug2023 vid: 31 iid: 147 pid: 65276 pub: Zanjan University of Medical Sciences & Health Services artinfo: ui: 175221099 175221099 175221099 10.30699/jambs.31.147.381 175221099 ppf: 381 ppct: 10 formats: fmt: @attributes: type: P tig: atl: The Influence of TNFRSF1B, PADI4, and miRNA 499 Gene Polymorphisms on Susceptibility and Responsiveness to TNF Inhibitors in Patients with Rheumatoid Arthritis. aug: au: Fadhil, Zainab Jumaah Hassan Abbas, Ahmed Abdul- Al-Osami, Mohammad Hadi affil: Dept. of Microbiology, College of Medicine, Al-Nahrain University, Kadhimiya, Iraq. sug: subj: Arthritis, Rheumatoid Drug Therapy Tumor Necrosis Factor Inhibitors Therapeutic Use Polymorphism, Genetic Disease Susceptibility MicroRNA Metabolism Receptors, Cell Surface Therapeutic Use Human Genotype Polymerase Chain Reaction Male Female Adult Arthritis, Rheumatoid Diagnosis Cytogenetic Analysis Data Analysis Software Descriptive Statistics Chi Square Test Middle Age Aged Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background & Objective: Rheumatoid arthritis (RA) is a systemic autoimmune disease that causes joint deterioration. Over the past decade, the primary approach to treat RA has relied on biological medications. Despite confirming the effectiveness of this therapy, patients have shown significant diversity in their clinical responses to treatment. This variability can be attributed to various genetic polymorphisms that influence the response to biological drugs. This study was conducted to investigate whether TNFRSF1B (rs1061622), PADI4 (rs1748033), and miRNA 499 (rs3746444) gene polymorphisms are associated with susceptibility and responsiveness to TNF-α inhibitors in RA patients. Materials & Methods: 100 RA patients (50 responders and 50 non-responders) and 100 apparently healthy subjects as the control group were studied. Genotyping of the polymorphisms was carried out using real-time polymerase chain reaction (PCR) with the TaqMan allelic discrimination assay. Results: The frequency of TG (P0.039) and GG genotypes of TNFRSF1B (rs1061622) were higher in RA patients than in the control group. At the alleles level the mutant G allele was significantly more frequent among patients than control group (P=0.018). For PADI4 (rs1748033), the mutant C allele was more frequent among patients than controls (P=0.041). Sub-dividing of patients into responders and nonresponders revealed that the mutant homozygous CC genotype of PADI4 (rs1748033) was significantly more frequent in non-responders than responders patients (P=0.046). AG genotype (P=0.016) and G allele (P=0.036) of miRNA 499a (rs3746444) were more frequent in non-responders than responders. Conclusion: Variant genotypes of TNFRII (Rs1061622) and PADI4 (rs1748033), may be associated with an increased risk of RA while PADI4 (rs1748033) and miRNA-499a (rs3746444) polymorphism may be associated with non-response to infliximab. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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