Musculoskeletal involvement in systemic lupus erythematosus: a contrast-enhanced magnetic resonance imaging study in 107 subjects.
Objective Joint involvement in SLE is the most frequent manifestation and shows a wide heterogeneity. It has not a valid classification and it is often underestimated. Subclinical inflammatory musculoskeletal involvement is not well known. We aim to describe the prevalence of joint and tendon involv...
| Publicado en: | Rheumatology Vol. 63; no. 2; pp. 423 - 430 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Feb2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175238971&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175238971 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14620324 DN9 jtl: Rheumatology issn: 14620324 maglogo: N pubinfo: dt: Feb2024 vid: 63 iid: 2 pid: 622 pub: Oxford University Press / USA artinfo: ui: 175238971 175238971 175238971 10.1093/rheumatology/kead223 175238971 ppf: 423 ppct: 7 formats: tig: atl: Musculoskeletal involvement in systemic lupus erythematosus: a contrast-enhanced magnetic resonance imaging study in 107 subjects. aug: au: Garcia, Patricia Corzo Garcia-Duitama, Ivan Claramunt, Anna Agustí Jordà, Xavier Duran Monfort, Jordi Salman-Monte, Tarek C affil: Rheumatology Department, Hospital Clínic de Barcelona , Barcelona, Spain sug: subj: Lupus Erythematosus, Systemic Complications Lupus Erythematosus, Systemic Diagnosis Contrast Media Diagnostic Use Image Enhancement Magnetic Resonance Imaging Musculoskeletal Diseases Epidemiology Hand Pathology Wrist Pathology Arthritis Diagnosis Arthralgia Diagnosis Human Male Female Adult Middle Age Comparative Studies Musculoskeletal System Physiology Osteoarthritis, Hand Osteoarthritis, Wrist Bone Marrow Diseases Synovitis Tenosynovitis Funding Source Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Objective Joint involvement in SLE is the most frequent manifestation and shows a wide heterogeneity. It has not a valid classification and it is often underestimated. Subclinical inflammatory musculoskeletal involvement is not well known. We aim to describe the prevalence of joint and tendon involvement in hand and wrist of SLE patients, either with clinical arthritis, arthralgia or asymptomatic and compare it with healthy subjects using contrasted MRI. Methods SLE patients fulfilling SLICC criteria were recruited and classified as follows: group (G) 1: hand/wrist arthritis, G2: hand/wrist arthralgia, G3: no hand/wrist symptoms. Jaccoud arthropathy, CCPa and RF positivity, hand OA or surgery were excluded. Healthy subjects (HS) were recruited as controls: G4. Contrasted MRI of non-dominant hand/wrist was performed. Images were evaluated following RAMRIS criteria extended to PIP, Tenosynovitis score for RA and peritendonitis from PsAMRIS. Groups were statistically compared. Results A total of 107 subjects were recruited (G1: 31, G2:31, G3:21, G4:24). Any lesion: SLE patients 74.7%, HS 41.67%; P 0.002. Synovitis: G1: 64.52%, G2: 51.61%, G3: 45%, G4: 20.83%; P 0.013. Erosions: G1: 29.03%; G2: 54.84%, G3: 47.62%; G4: 25%; P 0.066. Bone marrow oedema: G1: 29.03%, G2: 22.58%, G3: 19.05%, G4: 0.0%; P 0.046. Tenosynovitis: G1: 38.71%; G2: 25.81%, G3: 14.29%, G4: 0.0%; P 0.005. Peritendonitis: G1: 12.90%; G2: 3.23%, G3: 0.0%, G4: 0.0%; P 0.07. Conclusion SLE patients have a high prevalence of inflammatory musculoskeletal alterations confirmed by contrasted MRI, even if asymptomatic. Not only tenosynovitis but peritendonitis is also present. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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