Efficacy and safety of self-expanding metal stents in patients with inoperable esophageal cancer: a real-life study.
Background: Dysphagia is the most frequent symptom in patients diagnosed with esophageal cancer. Self-expanding metal stents (SEMS) are the current palliative treatment of choice for dysphagia in patients with non-curable esophageal cancer. This study aimed to evaluate the efficacy and adverse event...
| Publicado en: | Therapeutic Advances in Gastrointestinal Endoscopy Vol. 16; pp. 1 - 11 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Jan-Dec2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175250509&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175250509 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 26317745 M8AA jtl: Therapeutic Advances in Gastrointestinal Endoscopy issn: 26317745 maglogo: Y pubinfo: dt: Jan-Dec2023 vid: 16 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 175250509 175250509 175250509 10.1177/26317745231200975 175250509 ppf: 1 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Efficacy and safety of self-expanding metal stents in patients with inoperable esophageal cancer: a real-life study. aug: au: Miguel Jiménez-Gutiérrez, José Octavio Alonso-Lárraga, Juan Hernández-Guerrero, Angélica I. Saul Lino-Silva, Leonardo Olivas-Martinez, Antonio affil: Department of Endoscopy, Instituto Nacional de Cancerología, San Fernando 22, Tlalpan, Ciudad de México 14080, México sug: subj: Stents Metals Esophageal Neoplasms Surgery Deglutition Disorders Palliative Care Stents Adverse Effects Treatment Outcomes Evaluation Human Retrospective Design Tertiary Health Care Descriptive Statistics Male Female Pretest-Posttest Design Body Weight Changes T-Tests Cox Proportional Hazards Model Data Analysis Software Middle Age Middle Aged: 45-64 years Male Female ab: Background: Dysphagia is the most frequent symptom in patients diagnosed with esophageal cancer. Self-expanding metal stents (SEMS) are the current palliative treatment of choice for dysphagia in patients with non-curable esophageal cancer. This study aimed to evaluate the efficacy and adverse events (AEs) of different types of SEMS for palliation of dysphagia. Methods: We performed a retrospective cohort study of patients with advanced esophageal cancer and SEMS placement for dysphagia palliation in a tertiary care center. The primary outcome was the clinical success defined as an improvement in dysphagia (reduction of at least 2 points in the Mellow-Pinkas scoring system for dysphagia) after SEMS placement. Results: Between January 1999 and May 2020, 295 patients with esophageal cancer were identified. Among them, 75 had a SEMS placement for dysphagia palliation. The mean age of the patients was 61.3 years (standard deviation: 13.4), 69 patients (92%) were men, and the mean Mellow-Pinkas scoring for dysphagia pre- and post-SEMS placement were 3.1 and 1.4 (change from baseline -1.7), respectively. Technical success and clinical success were achieved in 98.6% and 58.9%, respectively. AEs were identified in 35/75 patients (46.7%), and SEMS migration was the most frequent AE in 22/75 patients (29.3%). There were no significant differences in improvement in dysphagia (p = 0.054), weight changes (p = 0.78), and AE (p = 0.73) among fully covered SEMS (fc-SEMS) and partially covered SEMS (pc-SEMS). The median follow-up was 89 days (interquartile range: 29-221). Conclusion: SEMS placement was associated with a rapid improvement in dysphagia, high technical success, and a modest improvement in dysphagia with no major AE among fc-SEMS and pc-SEMS. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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