Risk Factors for Distant Metastasis in T3 T4 Rectal Cancer.
Background: Distant metastasis is the leading cause of death in patients with rectal cancer. This study aims to comprehensively analyze the risk factors of distant metastasis in T3 T4 rectal cancer using magnetic resonance imaging (MRI), pathological features, and serum indicators. Methods: The clin...
| Publicado en: | Clinical Medicine Insights: Oncology pp. 1 - 13 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
2/5/2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175257146&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175257146 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11795549 B3KT jtl: Clinical Medicine Insights: Oncology issn: 11795549 maglogo: Y pubinfo: dt: 2/5/2024 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 175257146 175257146 175257146 10.1177/11795549241227423 175257146 ppf: 1 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Risk Factors for Distant Metastasis in T3 T4 Rectal Cancer. aug: au: Tang, Cui Xu, Jinming Lin, Moubin Qiu, Shixiong Wang, Huan Zuo, Xiaoming Liu, Mengxiao Wang, Peijun affil: Department of Radiology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China sug: subj: Neoplasm Metastasis Risk Factors Rectal Neoplasms Pathology Neoplasm Staging Magnetic Resonance Imaging Tumor Markers, Biological Blood Risk Assessment Human Retrospective Design Prospective Studies Rectal Neoplasms Surgery Logistic Regression Multiple Logistic Regression Descriptive Statistics Univariate Statistics Models, Statistical Odds Ratio Confidence Intervals Lymph Nodes ROC Curve Academic Medical Centers China Tomography, X-Ray Computed T-Tests Mann-Whitney U Test Chi Square Test Fisher's Exact Test Data Analysis Software Adult Middle Age Aged Aged, 80 and Over Liver Neoplasms Risk Factors Lung Neoplasms Risk Factors Peritoneal Neoplasms Risk Factors Multivariate Analysis Male Female Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Background: Distant metastasis is the leading cause of death in patients with rectal cancer. This study aims to comprehensively analyze the risk factors of distant metastasis in T3 T4 rectal cancer using magnetic resonance imaging (MRI), pathological features, and serum indicators. Methods: The clinicopathological data of 146 cases of T3 T4 rectal cancer after radical resection from January 2015 to March 2023 were retrospectively analyzed. Pre- and postoperative follow-up data of all cases were collected to screen for distant metastatic lesions. Univariate and multivariate Logistic regression methods were used to analyze the relationship between MRI features, pathological results, serum test indexes, and distant metastasis. Results: Of the 146 included patients, synchronous or metachronous distance metastasis was confirmed in 43 (29.4%) cases. The patients' baseline data and univariate analysis showed that mrEMVI, maximum tumor diameter, mr T Stage, pathological N stage, number of lymph node metastasis, cancer nodules, preoperative serum CEA, (Carcinoembryonic antigen) and CA199 were associated with distant metastasis. In the multiple logistic regression model, mrEMVI, pathological N stage, number of lymph node metastasis, maximum tumor diameter, and preoperative serum CEA were identified as independent risk factors for distant metastasis: mrEMVI [odds ratio (OR) = 3.06], pathological N stage (OR = 6.52 for N1 vs N0; OR = 63.47 for N2 vs N0), preoperative serum CEA (OR = 0.27), tumor maximum diameter (OR = 1.03), number of lymph nodes metastasis (OR = 0.62). And, the receiver operating characteristic (ROC) curve was plotted and the area under the curve was calculated (area under the curve [AUC) = 0.817, 95% CI = 0.744-0.890, P <.001]. Conclusions: mrEMVI, pathological N stage, number of lymph node metastasis, maximum tumor diameter and preoperative serum CEA are the independent risk factors for distant metastasis in T3 T4 rectal cancer. A comprehensive analysis of the risk factors for distant metastasis in rectal cancer can provide a reliable basis for formulating individualized treatment strategies, follow-up plans, and evaluating prognosis. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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