Challenges of pediatric pharmacotherapy: A narrative review of pharmacokinetics, pharmacodynamics, and pharmacogenetics.
Purpose: Personalized pharmacotherapy, including for the pediatric population, provides optimal treatment and has emerged as a major trend owing to advanced drug therapeutics and diversified drug selection. However, it is essential to understand the growth and developmental characteristics of this p...
| Published in: | European Journal of Clinical Pharmacology Vol. 80; no. 2; pp. 203 - 222 |
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| Main Authors: | , , , , , |
| Format: | pictorial research systematic review tables/charts Journal Article |
| Published: |
Springer Nature
Feb2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175280740&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175280740 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Feb2024 vid: 80 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 175280740 174150823 175280740 175280740 10.1007/s00228-023-03598-x 175280740 ppf: 203 ppct: 19 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Challenges of pediatric pharmacotherapy: A narrative review of pharmacokinetics, pharmacodynamics, and pharmacogenetics. aug: au: Watanabe, Hirofumi Nagano, Nobuhiko Tsuji, Yasuhiro Noto, Nobutaka Ayusawa, Mamoru Morioka, Ichiro affil: https://ror.org/05jk51a88 Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1 Kami-cho Ooyaguchi, Itabashi-ku, 173-8610, Tokyo, Japan sug: subj: Pediatrics Methods Disease Drug Therapy Pharmacogenetics Standards Pharmacokinetics Standards Pharmacy and Pharmacology Standards Human Child Systematic Review Child Development Drug Interactions Adverse Drug Event Drug Monitoring Methods Biological Markers Health Personnel Psychosocial Factors Health Care Delivery Risk Assessment Child: 6-12 years ab: Purpose: Personalized pharmacotherapy, including for the pediatric population, provides optimal treatment and has emerged as a major trend owing to advanced drug therapeutics and diversified drug selection. However, it is essential to understand the growth and developmental characteristics of this population to provide appropriate drug therapy. In recent years, clinical pharmacogenetics has accumulated knowledge in pediatric pharmacotherapy, and guidelines from professional organizations, such as the Clinical Pharmacogenetics Implementation Consortium, can be consulted to determine the efficacy of specific drugs and the risk of adverse effects. However, the existence of a large knowledge gap hinders the use of these findings in clinical practice. Methods: We provide a narrative review of the knowledge gaps in pharmacokinetics (PK) and pharmacodynamics (PD) in the pediatric population, focusing on the differences from the perspective of growth and developmental characteristics. In addition, we explored PK/PD in relation to pediatric clinical pharmacogenetics. Results: The lack of direct and indirect biomarkers for more accurate assessment of the effects of drug administration limits the current knowledge of PD. In addition, incorporating pharmacogenetic insights as pivotal covariates is indispensable in this comprehensive synthesis for precision therapy; therefore, we have provided recommendations regarding the current status and challenges of personalized pediatric pharmacotherapy. The integration of clinical pharmacogenetics with the health care system and institution of educational programs for health care providers is necessary for its safe and effective implementation. A comprehensive understanding of the physiological and genetic complexities of the pediatric population will facilitate the development of effective and personalized pharmacotherapeutic strategies. pubtype: Academic Journal doctype: pictorial research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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