Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies.
Background Fluoride may be a developmental neurotoxicant at elevated exposures. We merged new data from a prospective Odense Child Cohort (OCC) with results from two previous birth cohort studies from Mexico and Canada to characterize the dose–effect relationship in greater detail. Methods The OCC c...
| Publicado en: | European Journal of Public Health Vol. 34; no. 1; pp. 143 - 150 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Feb2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175366336&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175366336 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11011262 BHW jtl: European Journal of Public Health issn: 11011262 maglogo: N pubinfo: dt: Feb2024 vid: 34 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 175366336 175366336 175366336 10.1093/eurpub/ckad170 175366336 ppf: 143 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies. aug: au: Grandjean, Philippe Meddis, Alessandra Nielsen, Flemming Beck, Iben H Bilenberg, Niels Goodman, Carly V Hu, Howard Till, Christine Budtz-Jørgensen, Esben affil: Department of Environmental Medicine, University of Southern Denmark , Odense, Denmark sug: subj: Prenatal Exposure Delayed Effects Fluorides Adverse Effects Cognition Disorders Etiology Cognition Disorders Chemically Induced Abnormalities, Drug-Induced Dose-Response Relationship Developmental Disabilities Prospective Studies Mexico Neurotoxicity Syndromes Creatinine Maternal-Child Health Urinalysis Scales Fluorides Urine Confidence Intervals Funding Source Child Canada Mexico Benchmarking Human Male Female Prospective Studies Canada Child: 6-12 years Male Female ab: Background Fluoride may be a developmental neurotoxicant at elevated exposures. We merged new data from a prospective Odense Child Cohort (OCC) with results from two previous birth cohort studies from Mexico and Canada to characterize the dose–effect relationship in greater detail. Methods The OCC contributed 837 mother–child pairs to the total of >1500. We measured creatinine-adjusted urine-fluoride concentrations in maternal urine samples obtained during late pregnancy. Child IQ was determined at age 7 years using an abbreviated version of the Wechsler Intelligence Scales for Children. Findings from the three cohorts were used to calculate the joint benchmark concentration (BMC) and the lower confidence limit (BMCL) after adjustment for covariables. Results In the OCC, urine-fluoride concentrations varied between 0.08 and 3.04 mg/l (median 0.52 mg/l) but were not significantly associated with full-scale IQ at age 7 years (β = 0.08; 95% confidence interval −1.14 to 1.30 for a doubling in exposure). No difference was apparent between boys and girls. In the OCC, the BMC was 0.92 mg/l, with a BMCL of 0.30 mg/l. The joint analysis of all three cohorts showed a statistically significant association between urine-fluoride and IQ, with a BMC of 0.45 mg/l (BMCL, 0.28 mg/l), slightly higher than the BMC previously reported for the two North American cohorts alone. Conclusions As the BMCL reflects an approximate threshold for developmental neurotoxicity, the results suggest that pregnant women and children may need protection against fluoride toxicity. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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