Estimated Intake of Potassium, Phosphorus and Zinc with the Daily Diet Negatively Correlates with ADP-Dependent Whole Blood Platelet Aggregation in Older Subjects.
The aggregation of blood platelets is the pivotal step that leads to thrombosis. The risk of thrombotic events increases with age. Available data suggest that minerals taken with diet can affect the course of thrombosis. However, little is known about the relationship between platelet aggregability...
| Published in: | Nutrients Vol. 16; no. 3; pp. 332 - 348 |
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| Main Authors: | , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
MDPI
Feb2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175369008&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175369008 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Feb2024 vid: 16 iid: 3 pid: 97109 pub: MDPI artinfo: ui: 175369008 175369008 175369008 10.3390/nu16030332 175369008 ppf: 332 ppct: 16 formats: tig: atl: Estimated Intake of Potassium, Phosphorus and Zinc with the Daily Diet Negatively Correlates with ADP-Dependent Whole Blood Platelet Aggregation in Older Subjects. aug: au: Karolczak, Kamil Guligowska, Agnieszka Sołtysik, Bartłomiej K. Kostanek, Joanna Kostka, Tomasz Watala, Cezary affil: Department of Haemostatic Disorders, Medical University of Lodz, Ul. Mazowiecka 6/8, 92-215 Lodz, Poland sug: subj: Potassium Phosphorus Zinc Minerals Food Intake Diet Adenosine Diphosphate Platelet Aggregation In Middle Age Platelet Aggregation In Old Age Blood Platelets Physiology Arachidonic Acids Collagen Human Correlational Studies Male Female Middle Age Aged Spearman's Rank Correlation Coefficient Magnesium Iron Copper Manganese Portion Size Aging Thrombosis Prevention and Control Cardiovascular Risk Factors Prevention and Control Poland Funding Source Middle Aged: 45-64 years Aged: 65+ years Male Female ab: The aggregation of blood platelets is the pivotal step that leads to thrombosis. The risk of thrombotic events increases with age. Available data suggest that minerals taken with diet can affect the course of thrombosis. However, little is known about the relationship between platelet aggregability and mineral intake with diet among elderly people. Thus, we evaluated the associations between the reactivities of platelets to arachidonic acid, collagen or ADP and the estimated quantities of minerals consumed as a part of the daily diet in 246 subjects aged 60–65 years (124 men and 122 women). The found simple (not-adjusted) Spearman's rank negative correlations are as follows: 1. arachidonate-dependent aggregation and the amounts of potassium, zinc, magnesium, phosphorus, iron, copper and manganese; 2. collagen-dependent aggregation and the amounts of potassium, phosphorus, iron and zinc; and 3. ADP-dependent aggregation and the amounts of potassium, phosphorus and zinc. The negative associations between ADP-dependent platelet reactivity and the amount of potassium, phosphorus and zinc and between collagen-dependent aggregability and the amount of phosphorus were also noted after adjusting for a bunch of cardiovascular risk factors. Overall, in older subjects, the intake of minerals with diet is negatively related to blood platelet reactivity, especially in response to ADP. Diet fortification with some minerals may possibly reduce the thrombotic risk among elderly patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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