A Review of New Concepts in Iron Overload.
Iron overload disorders are conditions that can lead to increased body iron stores and end-organ damage in affected organs. Increased iron deposition most commonly occurs in the liver, heart, endocrine system, joints, and pancreas. Iron overload disorders may be caused by genetic or acquired causes...
| Publicado en: | Gastroenterology & Hepatology Vol. 20; no. 2; pp. 98 - 108 |
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| Autores principales: | , |
| Formato: | review tables/charts Journal Article |
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Gastro-Hep Communications, Inc
Feb2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175397516&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175397516 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15547914 6N5B jtl: Gastroenterology & Hepatology issn: 15547914 maglogo: N pubinfo: dt: Feb2024 vid: 20 iid: 2 pid: 72163 pub: Gastro-Hep Communications, Inc place: New York, New York artinfo: ui: 175397516 175397516 175397516 175397516 ppf: 98 ppct: 10 formats: fmt: @attributes: type: P tig: atl: A Review of New Concepts in Iron Overload. aug: au: Sohal, Aalam Kowdley, Kris V. affil: Liver Institute Northwest, Seattle, Washington sug: subj: Iron Overload Familial and Genetic Iron Liver Heart Endocrine System Joints Pancreas Blood Transfusion Liver Diseases Hemochromatosis Genes ab: Iron overload disorders are conditions that can lead to increased body iron stores and end-organ damage in affected organs. Increased iron deposition most commonly occurs in the liver, heart, endocrine system, joints, and pancreas. Iron overload disorders may be caused by genetic or acquired causes (transfusion, dyserythropoiesis, and chronic liver disease). The HFE gene C282Y homozygous mutation is the most common cause of hereditary hemochromatosis (HH). Other genes implicated in HH include TFR2, HAMP, HJV, and SLC40A1. In the past 2 decades, there have been major advances in the understanding of genetic iron overload disorders. Furthermore, new novel techniques to measure iron content in organs noninvasively, as well as new therapeutic options for the treatment of HH, are currently under development. This article focuses on the latest concepts in understanding, diagnosing, and managing genetic iron overload disorders, particularly HH. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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