Volume-based and Surface-Based Methods in Autism Compared with Healthy Controls Are Free surfer and CAT12 in Agreement?
Objectives: Autism Spectrum Disorder (ASD) encompasses a range of neurodevelopmental disorders, and early detection is crucial. This study aims to identify the Regions of Interest (ROIs) with significant differences between healthy controls and individuals with autism, as well as evaluate the agreem...
| Published in: | Iranian Journal of Child Neurology Vol. 18; no. 1; pp. 93 - 119 |
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| Main Authors: | , , , , , |
| Format: | research tables/charts Journal Article |
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Iranian Journal of Child Neurology
Winter2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175433843&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175433843 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17354668 A91T jtl: Iranian Journal of Child Neurology issn: 17354668 maglogo: N pubinfo: dt: Winter2024 vid: 18 iid: 1 pid: 56766 pub: Iranian Journal of Child Neurology place: Tehran, <Blank> artinfo: ui: 175433843 175433843 175433843 10.22037/IJCN.V18i1.43294 175433843 ppf: 93 ppct: 26 formats: fmt: @attributes: type: P tig: atl: Volume-based and Surface-Based Methods in Autism Compared with Healthy Controls Are Free surfer and CAT12 in Agreement? aug: au: FARAJI, Reyhane GANJI, Zohreh KHANDAN KHADEM, Zahra AKBARI-LALIMI, Hossein EIDY, Fereshteh ZARE, Hoda affil: Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran sug: subj: Autism Spectrum Disorder Physiopathology Gray Matter Physiology Human Child Male Female Descriptive Statistics Regression Analysis of Covariance Child: 6-12 years Male Female ab: Objectives: Autism Spectrum Disorder (ASD) encompasses a range of neurodevelopmental disorders, and early detection is crucial. This study aims to identify the Regions of Interest (ROIs) with significant differences between healthy controls and individuals with autism, as well as evaluate the agreement between FreeSurfer 6 (FS6) and Computational Anatomy Toolbox (CAT12) methods. Materials & Methods ISurface-based and volume-based features were extracted from FS software and CAT12 toolbox for Statistical Parametric Mapping (SPM) software to estimate ROI-wise biomarkers. These biomarkers were compared between 18 males Typically Developing Controls (TDCs) and 40 male subjects with ASD to assess group differences for each method. Finally, agreement and regression analyses were performed between the two methods for TDCs and ASD groups. Results Both methods revealed ROIs with significant differences for each parameter. The Analysis of Covariance (ANCOVA) showed that both TDCs and ASD groups indicated a significant relationship between the two methods (p<0.001). The R2 values for TDCs and ASD groups were 0.692 and 0.680, respectively, demonstrating a moderate correlation between CAT12 and FS6. Bland-Altman graphs showed a moderate level of agreement between the two methods. Conclusion The moderate correlation and agreement between CAT12 and FS6 suggest that while some consistency is observed in the results, CAT12 is not a superior substitute for FS6 software. Further research is needed to identify a potential replacement for this method. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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