Antidepressant deprescribing: State of the art and recommendations—A literature overview.
Introduction: In recent years, the consumption of antidepressants has arisen. However, deprescribing antidepressant therapy is very complicated. The aim of this study was to implement practical recommendations for the development of guidelines to be used for antidepressant deprescription in clinical...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 80; no. 3; pp. 417 - 434 |
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| Autores principales: | , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175530175&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175530175 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Mar2024 vid: 80 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 175530175 174656930 175530175 175530175 10.1007/s00228-023-03617-x 175530175 ppf: 417 ppct: 17 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Antidepressant deprescribing: State of the art and recommendations—A literature overview. aug: au: Romagnoli, Alessia Zovi, Andrea Santoleri, Fiorenzo Lasala, Ruggero affil: Territorial Pharmaceutical Service, Local Health Unit Lanciano Vasto Chieti, Chieti, Italy sug: subj: Antidepressive Agents Deprescribing Evaluation Practice Guidelines Program Development Medical Practice Education, Clinical Human Systematic Review PubMed Descriptive Statistics Cholinergic Antagonists Serotonin Uptake Inhibitors Antidepressive Agents, Tricyclic Nurses Pharmacists Multidisciplinary Care Team ab: Introduction: In recent years, the consumption of antidepressants has arisen. However, deprescribing antidepressant therapy is very complicated. The aim of this study was to implement practical recommendations for the development of guidelines to be used for antidepressant deprescription in clinical practice. Materials and methods: The literature search has been conducted on March 13, 2023, using Scopus and PubMed databases. The following search string has been used: "antidepressants AND (deprescribing OR deprescription)". All studies reporting a deprescribing intervention for antidepressant medication, regardless of the study design, have been included. Studies that did not report antidepressant drug deprescription interventions and non-English-language papers have been excluded. Results: From the literature search, a total of 230 articles have been extracted. Applying the exclusion criteria, 26 articles have been considered eligible. Most of the analyzed studies (16, 61%) have been carried out in the real world, 3 (11%) were RCTs, 5 (19%) were qualitative studies, in particular expert opinions, 1 (4%) was a literature review, and 1 (4%) was a post-trial observational follow-up of an RCT. In 8 out of 26 studies (31%), the analyzed antidepressants have been specified: 2 (8%) focused on anticholinergics, 2 (8%) on SSRIs, 3 (11%) on tricyclic antidepressants, and 1 (4%) on esketamine. Nineteen out of 26 studies (73%) did not stratify antidepressants by therapeutic class. The sample sizes analyzed in the studies ranged from a minimum of 4 patients to a maximum of 113,909, and 12 studies included geriatric age as an inclusion criterion. A patient's therapy review has been the main deprescribing intervention, and it has been identified in 14 (54%) articles. Interventions have been carried out by clinicians in 4 (15%) studies, general practitioners in 5 (19%) studies, nurses in 2 (8%) studies, pharmacists in 4 (15%) studies, multidisciplinary teams in 10 (38%) studies, and patients in 1 (4%) study. Conclusions: From the literature review, it emerged that there is no clear evidence useful to support clinicians in antidepressant deprescribing interventions. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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