Wound Debridement in Pyoderma Gangrenosum.

BACKGROUND: Wound debridement improves healing in a variety of acute and chronic ulcers. However, there is concern that debridement may trigger pathergy and worsen pyoderma gangrenosum (PG). OBJECTIVE: To determine whether published evidence supports conservative wound debridement for PG. DATA SOURC...

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Publicado en:Advances in Skin & Wound Care Vol. 37; no. 2; pp. 107 - 112
Autores principales: Taheri, Arash, Mansoori, Parisa, Sharif, Mohammad
Formato: review tables/charts Journal Article
Publicado: Lippincott Williams & Wilkins Feb2024
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Feb2024
      vid: 37
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      pub: Lippincott Williams & Wilkins
      place: Baltimore, Maryland
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        atl: Wound Debridement in Pyoderma Gangrenosum.
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        au:
          Taheri, Arash
          Mansoori, Parisa
          Sharif, Mohammad
        affil: InternalMedicine Physician, JenCare Senior Medical Center, Atlanta, Georgia, United States
      sug:
        subj:
          Surgical Debridement
          Pyoderma Gangrenosum Surgery
          Treatment Outcomes
          Pyoderma Gangrenosum Microbiology
          Conservative Treatment
          Wound Healing
          Medline
          Biofilms
          Immunosuppressive Agents
      ab: BACKGROUND: Wound debridement improves healing in a variety of acute and chronic ulcers. However, there is concern that debridement may trigger pathergy and worsen pyoderma gangrenosum (PG). OBJECTIVE: To determine whether published evidence supports conservative wound debridement for PG. DATA SOURCES: The authors reviewed the literature published in MEDLINE through January 2023 using the search germs "pyoderma gangrenosum" and "debridement." STUDY SELECTION: Articles reporting sharp surgical debridement or maggot debridement for PG were included in the review. The authors also searched the reference sections of the reviewed articles for additional reports on debridement for PG. DATA EXTRACTION: Clinical data regarding patient status, procedures performed, and patient outcomes were extracted from the selected articles. DATA SYNTHESIS: There are multiple reports of uncontrolled, active-phase PG wounds worsening after aggressive excisional debridement of viable inflamed tissues. In contrast, there is no evidence indicating that conservative debridement of nonviable necrotic tissue worsens PG wounds, regardless of the disease activity. There are multiple reports of successful debridement and surgical grafting for PG in remission. CONCLUSIONS: There is no evidence in favor of or against using conservative debridement of nonviable necrotic tissue for a PG wound. Therefore, it should not be considered contraindicated, even in the active phase of the disease.
      pubtype: Academic Journal
      doctype:
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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