Identifying locally actionable strategies to increase participant acceptability and feasibility to participate in Phase I cancer clinical trials.
Background: Recruitment of cancer clinical trial (CCT) participants, especially participants representing the diversity of the US population, is necessary to create successful medications and a continual challenge. These challenges are amplified in Phase I cancer trials that focus on evaluating the...
| Publicado en: | Health Expectations Vol. 27; no. 1; pp. 1 - 12 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Feb2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175641762&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175641762 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13696513 EVY jtl: Health Expectations issn: 13696513 maglogo: Y pubinfo: dt: Feb2024 vid: 27 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 175641762 173914435 175641762 175641762 10.1111/hex.13920 175641762 ppf: 1 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Identifying locally actionable strategies to increase participant acceptability and feasibility to participate in Phase I cancer clinical trials. aug: au: Staras, Stephanie A. S. Wollney, Easton N. Emerson, Lisa E. Silver, Natalie Dziegielewski, Peter T. Hansen, Marta D. Sanchez, Gabriela D'Ingeo, Dalila Johnson‐Mallard, Versie Renne, Rolf Fredenburg, Kristianna Gutter, Michael Zamojski, Kendra Vandeweerd, Carla Bylund, Carma L. affil: Department of Health Outcomes and Biomedical Informatics, University of Florida College of Medicine, Gainesville Florida,, USA sug: subj: Strategic Planning Consumer Participation Clinical Trials Human Patient Safety Head and Neck Neoplasms Qualitative Studies Semi-Structured Interview Race Factors Ethnic Groups Content Analysis Thematic Analysis Professional Knowledge Interpersonal Relations Life Experiences Oncology Patient Education Descriptive Statistics Funding Source Adult Middle Age Aged Aged, 80 and Over Male Female Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Background: Recruitment of cancer clinical trial (CCT) participants, especially participants representing the diversity of the US population, is necessary to create successful medications and a continual challenge. These challenges are amplified in Phase I cancer trials that focus on evaluating the safety of new treatments and are the gateway to treatment development. In preparation for recruitment to a Phase I recurrent head and neck cancer (HNC) trial, we assessed perceived barriers to participation or referral and suggestions for recruitment among people with HNC and community physicians (oncologist, otolaryngologist or surgeon). Methods: Between December 2020 and February 2022, we conducted a qualitative needs assessment via semistructured interviews with a race and ethnicity‐stratified sample of people with HNC (n = 30: 12 non‐Hispanic White, 9 non‐Hispanic African American, 8 Hispanic and 1 non‐Hispanic Pacific Islander) and community physicians (n = 16) within the University of Florida Health Cancer Center catchment area. Interviews were analyzed using a qualitative content analysis approach to describe perspectives and identify relevant themes. Results: People with HNC reported thematic barriers included: concerns about side effects, safety and efficacy; lack of knowledge and systemic and environmental obstacles. Physicians identified thematic barriers of limited physician knowledge; clinic and physician barriers and structural barriers. People with HNC and physicians recommended themes included: improved patient education, dissemination of trial information and interpersonal communication between community physicians and CCT staff. Conclusions: The themes identified by people with HNC and community physicians are consistent with research efforts and recommendations on how to increase the participation of people from minoritized populations in CCTs. This community needs assessment provides direction on the selection of strategies to increase CCT participation and referral. Patient or Public Contribution: This study focused on people with HNC and community physicians' lived experience and their interpretations of how they would consider a future Phase I clinical trial. In addition to our qualitative data reflecting community voices, a community member reviewed the draft interview guide before data collection and both people with HNC and physicians aided interpretation of the findings. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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