Effects of fecal microbiota transplantation for recurrent Clostridium difficile infection in children on kidney replacement therapy: a pilot study.
Background: Recurrent Clostridium difficile infection (rCDI) is a rising problem in children with chronic diseases. Fecal microbiota transplantation (FMT) is a recent alternative for rCDI patients who do not respond to conventional treatment. FMT could have an additional positive effect on the intes...
| Publicado en: | Pediatric Nephrology Vol. 39; no. 4; pp. 1201 - 1213 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175695424&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175695424 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Apr2024 vid: 39 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 175695424 172388148 175695424 175695424 10.1007/s00467-023-06168-6 175695424 ppf: 1201 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effects of fecal microbiota transplantation for recurrent Clostridium difficile infection in children on kidney replacement therapy: a pilot study. aug: au: Samaey, An Vázquez-Castellanos, Jorge Francisco Caenepeel, Clara Evenepoel, Pieter Vermeire, Séverine Raes, Jeroen Knops, Noël affil: https://ror.org/0424bsv16 Department of Pediatric Nephrology and Solid Organ Transplantation, UZ Leuven, Leuven, Belgium sug: subj: Fecal Microbiota Transplantation Methods Fecal Microbiota Transplantation Utilization Clostridioides Difficile Metabolism Uremia Metabolism Renal Replacement Therapy Treatment Outcomes Human Male Female Infant Child, Preschool Child Case Studies Descriptive Statistics Pilot Studies Alternative Therapies Intestinal Diseases Feces Analysis Uremic Toxins Kidney Failure, Chronic Hematologic Tests Inflammation Bacterial Infections Nephrotic Syndrome Diagnosis Vancomycin Therapeutic Use Metronidazole Hemodialysis Abdominal Pain Etiology Diarrhea Etiology Vomiting Etiology Pediatric Care Gut Microbiota Funding Source Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Male Female ab: Background: Recurrent Clostridium difficile infection (rCDI) is a rising problem in children with chronic diseases. Fecal microbiota transplantation (FMT) is a recent alternative for rCDI patients who do not respond to conventional treatment. FMT could have an additional positive effect on the intestinal dysbiosis and accumulation of uremic retention molecules (URM) associated with chronic kidney disease (CKD). Our aim was to investigate the clinical efficacy of FMT for rCDI in children with CKD together with the effect on dysbiosis and URM levels. Methods: We analyzed stool and blood samples before and until 3 months after FMT in 3 children between 4 and 8 years old with CKD and rCDI. The microbiome was analyzed by 16 s rRNA sequencing. URM were analyzed with ultra-performance liquid chromatography-tandem mass spectrometry. CRP and fecal calprotectin were analyzed as parameters for systemic and gut inflammation, respectively. Results: CDI resolved after FMT in all three without adverse events; one patient needed a second FMT. No significant effect on CRP and calprotectin was observed. Stool samples demonstrated a reduced richness and bacterial diversity which did not improve after FMT. We did observe a trend in the decrease of specific URM up to 3 months after FMT. Conclusion: FMT is an effective treatment for rCDI in patients with CKD. Analysis of the microbiome showed an important intestinal dysbiosis that, besides a significant reduction in Clostridium difficile, did not significantly change after FMT. A trend for reduction was seen in some of the measured URM after FMT. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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