Evaluation of endothelial dysfunction in hypertensive children and adolescents.
Background: Atherosclerotic changes can be attributed to early endothelial damage in individuals with hypertension. We aimed to explore the relationship between endothelial dysfunction and hypertension in newly diagnosed children without end-organ damage, considering carotid intima-media thickness (...
| Publicado en: | Pediatric Nephrology Vol. 39; no. 4; pp. 1193 - 1200 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175695444&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175695444 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Apr2024 vid: 39 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 175695444 173363896 175695444 175695444 10.1007/s00467-023-06205-4 175695444 ppf: 1193 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Evaluation of endothelial dysfunction in hypertensive children and adolescents. aug: au: Doğan, Kenan Başar, Eviç Zeynep Aytaç, Mehmet Baha Şahin, Nihal Bayrak, Yunus Emre Bek, Kenan Güngör, Hüseyin Salih Sönmez, Hafize Emine Babaoğlu, Kadir affil: https://ror.org/0411seq30 Department of Pediatric Nephrology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey sug: subj: Hypertension Diagnosis Hypertension Diagnosis Endothelium Carotid Intima-Media Thickness Angioscopy Methods Human Male Female Adolescence Cross Sectional Studies Volunteer Workers Antihypertensive Agents Therapeutic Use Essential Hypertension Drug Therapy Brachial Artery Early Diagnosis Atherosclerosis Complications Child Adolescent: 13-18 years Child: 6-12 years Male Female ab: Background: Atherosclerotic changes can be attributed to early endothelial damage in individuals with hypertension. We aimed to explore the relationship between endothelial dysfunction and hypertension in newly diagnosed children without end-organ damage, considering carotid intima-media thickness (CIMT), flow-mediated dilatation (FMD), and functional capillaroscopy parameters. We also analyzed the differences between dipper and non-dipper patients. Methods: In this cross-sectional study, 20 patients diagnosed with essential hypertension with no target organ damage, and 20 age and sex-matched healthy volunteers were enrolled. The patient group comprised newly diagnosed individuals not receiving antihypertensive treatment. Hypertensive patients were divided into two groups (dipper and non-dipper patients). The measurements of CIMT, brachial FMD, and functional capillaroscopy were performed before starting treatment. Results: Among the patients, 11 were boys, and 9 were girls, with a median age of 16.0 (2.13) years. Of 20 hypertensive patients, 10 were dipper and 10 were non-dipper. Significant differences were observed between the hypertensive patients and controls in terms of CIMT (p = 0.04), brachial artery FMD (p = 0.02), and functional capillary density (p < 0.001). Hypertensive patients exhibited increased CIMT, reduced brachial artery FMD, and lower capillary density. However, there were no differences between dippers and non-dippers regarding age, sex, height SDS, weight SDS, CIMT SDS, brachial artery FMD, and capillary density. Conclusions: Understanding the vascular consequences associated with essential hypertension emphasizes the importance of early detection and management of hypertension. Herein, we have effectively highlighted significant endothelial changes through the analysis of three parameters in newly diagnosed children without apparent target organ damage. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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