Added γ-oryzanol boosted anti-inflammatory effects of canola oil in adult subjects with type 2 diabetes: a randomized controlled clinical trial.
Purpose: This study was conducted to examine the effects of daily intake of γ-oryzanol (ORZ)-fortified canola oil, as compared with plain canola and sunflower oils, on certain inflammatory and oxidative stress biomarkers in adult subjects with Type 2 Diabetes (T2D). Methods: We randomly allocated 92...
| Publicado en: | European Journal of Nutrition Vol. 63; no. 2; pp. 425 - 434 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Mar2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175695768&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175695768 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Mar2024 vid: 63 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 175695768 173644965 175695768 175695768 10.1007/s00394-023-03275-w 175695768 ppf: 425 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Added γ-oryzanol boosted anti-inflammatory effects of canola oil in adult subjects with type 2 diabetes: a randomized controlled clinical trial. aug: au: Nikooyeh, Bahareh Zargaraan, Azizollaah Ebrahimof, Samira Kalayi, Ali Zahedirad, Maliheh Yazdani, Hootan Rismanchi, Marjan Karami, Taher Khazraei, Marzieh Jafarpour, Ali Neyestani, Tirang R. affil: Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran sug: subj: Diabetes Mellitus, Type 2 Drug Therapy Antiinflammatory Agents Pharmacodynamics Antiinflammatory Agents Therapeutic Use Phenylpropionates Biological Markers Immunity Human Male Female Adult Randomized Controlled Trials Rapeseed Oil Sunflower Oil Oxidative Stress Descriptive Statistics Middle Age Analysis of Variance Analysis of Covariance Comparative Studies Chi Square Test Data Analysis Software T-Tests Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Purpose: This study was conducted to examine the effects of daily intake of γ-oryzanol (ORZ)-fortified canola oil, as compared with plain canola and sunflower oils, on certain inflammatory and oxidative stress biomarkers in adult subjects with Type 2 Diabetes (T2D). Methods: We randomly allocated 92 adult subjects with T2D from both sexes to one of the following groups to receive: (a) ORZ-fortified canola oil (ORZO; n1 = 30); (b) unfortified canola oil (CANO; n2 = 32); or (c) sunflower oil (SUFO; n3 = 30) for 12 weeks. Dietary and laboratory evaluations were performed initially and finally. Results: Serum hs-CRP concentrations significantly decreased in ORZO group (from 3.1 ± 0.2 to 1.2 ± 0.2 mg/L), as compared with CANO (p = 0.003) and SUFO (p < 0.001) groups. Serum IL-6 significantly decreased just in ORZO (− 22.8%, p = 0.042) and CANO groups (− 19.8%, p = 0.038). However, the between-group differences were not significant. Serum IL-1β slightly decreased in ORZO (− 28.1%, p = 0.11) and increased in SUFO (+ 20.6%, p = 0.079) but between-group difference was statistically significant (p = 0.017). Serum IFN-γ concentrations decreased significantly only in ORZO (from 3.3 ± 0.08 to 2.9 ± 0.21 IU/mL, p = 0.044). Salivary IgA concentrations increased significantly in all three intervention groups. Notwithstanding, only the difference between ORZO and CANO groups was statistically significant (p = 0.042). Similarly, circulating malondialdehyde concentrations significantly decreased in all three groups but with no between-group significant difference. Conclusions: Daily consumption of ORZ-fortified canola oil, compared with unfortified canola and sunflower oils, for 12 weeks resulted in boosting of certain anti-inflammatory effects of canola oil. These findings may have preventive implications for both clinicians and policy makers. This clinical trial was registered at clinicaltrials.gov (03.08.2022; NCT05271045). pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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