A Comprehensive Mixed‐Method Approach to Characterize the Source of Diurnal Tacrolimus Exposure Variability in Children: Systematic Review, Meta‐analysis, and Application to an Existing Data Set.

Tacrolimus is widely reported to display diurnal variation in pharmacokinetic parameters with twice‐daily dosing. However, the contribution of chronopharmacokinetics versus food intake is unclear, with even less evidence in the pediatric population. The objectives of this study were to summarize the...

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Bibliographic Details

Published in:	Journal of Clinical Pharmacology Vol. 64; no. 3; pp. 334 - 345
Main Authors:	Leino, Abbie D., Magee, John C., Kershaw, David B., Pai, Manjunath P., Park, Jeong M.
Format:	meta analysis research systematic review tables/charts Journal Article
Published:	Wiley-Blackwell Mar2024
Online Access:	View this record in EBSCOhost