Prognostic Nutritional Index as a Predictive Biomarker of Post-Operative Infectious Morbidity in Gynecological Cancer Patients: A Prospective Cohort Study.
Malnutrition significantly impacts the post-operative process of gynecological cancer patients. A prominent variable for determining perioperative morbidity is the Prognostic Nutritional Index (PNI). To investigate PNI's predictive value on the risk of post-operative infections, we conducted a prosp...
| Publicado en: | Nutrition & Cancer Vol. 76; no. 4; pp. 364 - 372 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175794658&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175794658 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2024 vid: 76 iid: 4 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 175794658 175516579 175794658 175794658 10.1080/01635581.2024.2318827 175794658 ppf: 364 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Prognostic Nutritional Index as a Predictive Biomarker of Post-Operative Infectious Morbidity in Gynecological Cancer Patients: A Prospective Cohort Study. aug: au: Pergialiotis, Vasilios Thomakos, Nikolaos Papalios, Theodoros Lygizos, Vasilios Vlachos, Dimitrios Efthimios Rodolakis, Alexandros Haidopoulos, Dimitrios affil: First Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, "Alexandra" General Hospital, Athens, Greece sug: subj: Genital Neoplasms, Female Surgery Nutritional Assessment Biological Markers Blood Postoperative Period Genital Neoplasms, Female Prognosis Postoperative Complications Risk Factors Risk Assessment Morbidity Risk Factors Malnutrition Complications Surgical Wound Infection Risk Factors Abscess Risk Factors Urinary Tract Infections Risk Factors Lung Diseases Risk Factors Human Cancer Patients Perioperative Care Prospective Studies Female Descriptive Statistics Nutritional Status Univariate Statistics Leukocyte Count Multivariate Analysis Random Forest Female ab: Malnutrition significantly impacts the post-operative process of gynecological cancer patients. A prominent variable for determining perioperative morbidity is the Prognostic Nutritional Index (PNI). To investigate PNI's predictive value on the risk of post-operative infections, we conducted a prospective cohort study involving women who underwent surgery for gynecological malignancies. Out of the 208 patients enrolled, 28 (13.5%) were malnourished and post-operative infections occurred in 43 patients. Notably, there was a significant difference in PNI between patients who developed infections and those who did not (p = 0.027), as well as between malnourished patients and those with normal nutritional status (p = 0.043). Univariate analysis showed that preoperative PNI predicts the risk of post-operative infections better than post-operative white blood cell count (AUC of 0.562 vs 0.375). However, the most accurate diagnostic results in the multivariate analysis were obtained from random forest and classification tree models (AUC of 0.987 and 0.977, respectively). Essentially, PNI and post-operative white blood cell count provided the best information gain according to rank probabilities. In conclusion, PNI appears to be a critical parameter that merits further investigation during the preoperative evaluation of gynecological malignancies. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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