Disentangling the reasons why older adults do not readily participate in cancer trials: a socio-epidemiological mixed methods approach.
Background Few studies of the under-representation of older adults in cancer clinical trials (CTs) have encompassed the entire pathway from a trial being available in a cancer centre to the patient's invitation to participate and then agreement or refusal to participate. Objectives The study's prima...
| Publicado en: | Age & Ageing Vol. 53; no. 2; pp. 1 - 10 |
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| Autores principales: | , , , , , , , , , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Oxford University Press / USA
Feb2024
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=175800454&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 175800454 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Feb2024 vid: 53 iid: 2 pid: 622 pub: Oxford University Press / USA artinfo: ui: 175800454 10.1093/ageing/afae007 ppf: 1 ppct: 9 formats: tig: atl: Disentangling the reasons why older adults do not readily participate in cancer trials: a socio-epidemiological mixed methods approach. aug: au: Hagège, Meoïn Bringuier, Michaël Martinez-Tapia, Claudia Chouaïd, Christos Helissey, Carole Brain, Etienne Lempdes, Godelieve Rochette Dubot, Coraline Bello-Roufai, Diana Geiss, Romain Kempf, Emmanuelle Gourden, Audrey Elgharbi, Hanane Garrigou, Sonia Gregoire, Laetitia Derbez, Benjamin Canouï-Poitrine, Florence affil: Department of Health , French institute for health research, Institut Mondor de Recherche Biomédicale , InsermU955, Eq. CEpiA & University Paris Est Créteil, 8 rue du general Sarrail, F-94010 Créteil , France Institut Curie , 35 Rue Dailly, F-92210 Saint-Cloud , France Department of Pneumology, Centre Hospitalier Intercommunal Créteil , 40 Av. de Verdun, F-94000 Créteil , France Departement of Oncology, Hôpital d'Instruction des Armées Bégin , 69 Av. de Paris, F-94160 Saint-Mandé , France Department of Oncology, Hôpital Henri Mondor , 54 avenue du maréchal lattre de tassigny, F-94010 Créteil , France Department of Pneumology, Centre Hospitalier Intercommunal Créteil, 40 Av. de Verdun, F-94000 Créteil , France Department of Sociology, Université Paris 8, Cresspa CSU , 2 Rue de la Liberté, F-93200 Saint-Denis , France Department of Health, French institute for health research , Institut Mondor de Recherche Biomédicale, InsermU955, Eq. CEpiA & University Paris Est Créteil, 8 rue du general Sarrail, F-94010 Créteil, France su: France Clinical trials Human research subjects Participation Physician-patient relations Patients' attitudes Social isolation Sociodemographic factors Marital status Family relations Old age Cancer patient psychology Patient selection Attitudes of medical personnel Research methodology Descriptive statistics Research funding Tumors Thematic analysis Epidemiological research sug: subj: Clinical trials Human research subjects Participation Physician-patient relations Patients' attitudes Social isolation Sociodemographic factors Marital status Family relations Old age France Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology) Cancer patient psychology Patient selection Attitudes of medical personnel Research methodology Descriptive statistics Research funding Tumors Thematic analysis Epidemiological research keyword: cancer cancer trial divorced state inclusion non-invitation older adult older people participation perception refusal to participate widowhood cancer cancer trial divorced state inclusion non-invitation older adult older people participation perception refusal to participate widowhood ab: Background Few studies of the under-representation of older adults in cancer clinical trials (CTs) have encompassed the entire pathway from a trial being available in a cancer centre to the patient's invitation to participate and then agreement or refusal to participate. Objectives The study's primary objective was to evaluate CT non-invitation and refusal rates. The secondary objectives were to identify factors associated with non-invitation and refusal and to assess experiences of CT participation from the patients' and professionals' perspectives. Methods Here, we used mixed methods and a socio-epidemiological approach to analyse reasons for the non-participation of eligible older patients with a solid cancer in cancer CTs in France. Results We found that non-invitation and low CT participation are mainly related to the patients' sociodemographic characteristics and living conditions (such as social isolation, being single, divorced or widowed, not having children and the absence of close family members) and the healthcare professionals' perceptions of insufficient informal support or a high homecare requirement. Conclusion Our results suggest that efforts to increase fair inclusion and the participation of older adults in CTs should target the physician–patient relationship, the medical profession and hospital funding, rather than the patient alone. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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