Multiple Classification of Brain MRI Autism Spectrum Disorder by Age and Gender Using Deep Learning.

The fact that the rapid and definitive diagnosis of autism cannot be made today and that autism cannot be treated provides an impetus to look into novel technological solutions. To contribute to the resolution of this problem through multiple classifications by considering age and gender factors, in...

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Publicado en:Journal of Medical Systems Vol. 48; no. 1; pp. 1 - 13
Autores principales: Nogay, Hidir Selcuk, Adeli, Hojjat
Formato: diagnostic images equations & formulas research tables/charts Journal Article
Publicado: Springer Nature 1/22/2024
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 1/22/2024
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10916-023-02032-0
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        atl: Multiple Classification of Brain MRI Autism Spectrum Disorder by Age and Gender Using Deep Learning.
      aug:
        au:
          Nogay, Hidir Selcuk
          Adeli, Hojjat
        affil: https://ror.org/03tg3eb07 Electrical and Energy Department, Bursa Uludag University, Bursa, Turkey
      sug:
        subj:
          Autism Spectrum Disorder Diagnosis
          Deep Learning
          Brain Anatomy and Histology
          Magnetic Resonance Imaging
          Neuroradiography
          Age Factors
          Mental Disorders Diagnosed in Childhood
          Communicative Disorders
          Database Design
          Algorithms
      ab: The fact that the rapid and definitive diagnosis of autism cannot be made today and that autism cannot be treated provides an impetus to look into novel technological solutions. To contribute to the resolution of this problem through multiple classifications by considering age and gender factors, in this study, two quadruple and one octal classifications were performed using a deep learning (DL) approach. Gender in one of the four classifications and age groups in the other were considered. In the octal classification, classes were created considering gender and age groups. In addition to the diagnosis of ASD (Autism Spectrum Disorders), another goal of this study is to find out the contribution of gender and age factors to the diagnosis of ASD by making multiple classifications based on age and gender for the first time. Brain structural MRI (sMRI) scans of participators with ASD and TD (Typical Development) were pre-processed in the system originally designed for this purpose. Using the Canny Edge Detection (CED) algorithm, the sMRI image data was cropped in the data pre-processing stage, and the data set was enlarged five times with the data augmentation (DA) techniques. The most optimal convolutional neural network (CNN) models were developed using the grid search optimization (GSO) algorism. The proposed DL prediction system was tested with the five-fold cross-validation technique. Three CNN models were designed to be used in the system. The first of these models is the quadruple classification model created by taking gender into account (model 1), the second is the quadruple classification model created by taking into account age (model 2), and the third is the eightfold classification model created by taking into account both gender and age (model 3).). The accuracy rates obtained for all three designed models are 80.94, 85.42 and 67.94, respectively. These obtained accuracy rates were compared with pre-trained models by using the transfer learning approach. As a result, it was revealed that age and gender factors were effective in the diagnosis of ASD with the system developed for ASD multiple classifications, and higher accuracy rates were achieved compared to pre-trained models.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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