A right convergence area of the prefrontal lobe is involved in the improvement of semantic fluency in patients with post-stroke aphasia.
This study aimed to longitudinally observe the improvement mechanism of semantic fluency in subacute post-stroke aphasia (PSA) patients using resting-state functional magnetic resonance imaging (rs-fMRI). Twelve PSA patients, about one month after onset, were enrolled in this study and received spee...
| Publicado en: | Topics in Stroke Rehabilitation Vol. 31; no. 3; pp. 301 - 311 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Apr2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175910444&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175910444 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10749357 0OG jtl: Topics in Stroke Rehabilitation issn: 10749357 maglogo: N pubinfo: dt: Apr2024 vid: 31 iid: 3 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 175910444 171102231 175910444 175910444 10.1080/10749357.2023.2253632 175910444 ppf: 301 ppct: 10 formats: tig: atl: A right convergence area of the prefrontal lobe is involved in the improvement of semantic fluency in patients with post-stroke aphasia. aug: au: Feng, Tao Zhang, Chao Xu, Siwei Wang, Lingmin Xu, Kai Xie, Zhiyuan Xiang, Jie Chen, Weiwei affil: Department of Rehabilitation, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China sug: subj: Brain Physiology Prefrontal Cortex Semantics Evaluation Language Processing Evaluation Stroke Complications Aphasia Psychosocial Factors Aphasia Rehabilitation Magnetic Resonance Imaging Relaxation Human Adult Middle Age Funding Source Speech Therapy Language Therapy Data Analysis Software Prospective Studies Academic Medical Centers Language Tests Functional Connectivity Descriptive Statistics Pearson's Correlation Coefficient T-Tests Adult: 19-44 years Middle Aged: 45-64 years ab: This study aimed to longitudinally observe the improvement mechanism of semantic fluency in subacute post-stroke aphasia (PSA) patients using resting-state functional magnetic resonance imaging (rs-fMRI). Twelve PSA patients, about one month after onset, were enrolled in this study and received speech-language therapy (SLT) for one month. Auditory comprehension and semantic fluency were evaluated using the Western Aphasia Battery (WAB) and the Animal Fluency Test. Before and after treatment, rs-fMRI data were collected, and the dice similarity coefficient was used to measure the spatial similarity between each patient's lesion and a reference lesion. The left posterior inferior temporal gyrus (pITG) was used as a seed to calculate the normalized functional connectivity in whole-brain voxel analysis using DPABI software for statistical analysis. The dice similarity coefficient between each patient's lesion and the reference lesion showed moderate to high intensity (0.57 ± 0.14) in the Montreal Neurological Institute space. After treatment, we found a significant increase in functional connectivity between the left pITG and the right prefrontal lobe convergence area (peak t = 8.219, Gaussian random field multiple comparison correction, voxel p < 0.001, cluster p < 0.05). The increase in functional connectivity was negatively correlated with the improvement in auditory comprehension (r =–0.707, p = 0.033) and positively correlated with the improvement in semantic fluency (r = 0.79, p = 0.02). The improvement of semantic fluency in subacute PSA patients may require the participation of the right convergence area of the prefrontal lobe. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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