Generating PET Attenuation Maps via Sim2Real Deep Learning–Based Tissue Composition Estimation Combined with MLACF.

Deep learning (DL) has recently attracted attention for data processing in positron emission tomography (PET). Attenuation correction (AC) without computed tomography (CT) data is one of the interests. Here, we present, to our knowledge, the first attempt to generate an attenuation map of the human...

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Publicado en:Journal of Digital Imaging Vol. 37; no. 1; pp. 167 - 180
Autores principales: Kobayashi, Tetsuya, Shigeki, Yui, Yamakawa, Yoshiyuki, Tsutsumida, Yumi, Mizuta, Tetsuro, Hanaoka, Kohei, Watanabe, Shota, Morimoto‑Ishikawa, Daisuke, Yamada, Takahiro, Kaida, Hayato, Ishii, Kazunari
Formato: diagnostic images research tables/charts Journal Article
Publicado: Springer Nature Feb2024
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Feb2024
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10278-023-00902-0
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        atl: Generating PET Attenuation Maps via Sim2Real Deep Learning–Based Tissue Composition Estimation Combined with MLACF.
      aug:
        au:
          Kobayashi, Tetsuya
          Shigeki, Yui
          Yamakawa, Yoshiyuki
          Tsutsumida, Yumi
          Mizuta, Tetsuro
          Hanaoka, Kohei
          Watanabe, Shota
          Morimoto‑Ishikawa, Daisuke
          Yamada, Takahiro
          Kaida, Hayato
          Ishii, Kazunari
        affil: Technology Research Laboratory, Shimadzu Corporation, 3-9-4, Hikaridai, Seika-cho, Soraku-gun, 619-0237, Kyoto, Japan
      sug:
        subj:
          Positron-Emission Tomography
          Brain Mapping
          Deep Learning Methods
          Image Interpretation, Computer Assisted
          Tissue Analysis
          Human
          Funding Source
          Tomography, X-Ray Computed
      ab: Deep learning (DL) has recently attracted attention for data processing in positron emission tomography (PET). Attenuation correction (AC) without computed tomography (CT) data is one of the interests. Here, we present, to our knowledge, the first attempt to generate an attenuation map of the human head via Sim2Real DL-based tissue composition estimation from model training using only the simulated PET dataset. The DL model accepts a two-dimensional non-attenuation-corrected PET image as input and outputs a four-channel tissue-composition map of soft tissue, bone, cavity, and background. Then, an attenuation map is generated by a linear combination of the tissue composition maps and, finally, used as input for scatter+random estimation and as an initial estimate for attenuation map reconstruction by the maximum likelihood attenuation correction factor (MLACF), i.e., the DL estimate is refined by the MLACF. Preliminary results using clinical brain PET data showed that the proposed DL model tended to estimate anatomical details inaccurately, especially in the neck-side slices. However, it succeeded in estimating overall anatomical structures, and the PET quantitative accuracy with DL-based AC was comparable to that with CT-based AC. Thus, the proposed DL-based approach combined with the MLACF is also a promising CT-less AC approach.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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