Machine Learning-Based Multiparametric Magnetic Resonance Imaging Radiomics Model for Preoperative Predicting the Deep Stromal Invasion in Patients with Early Cervical Cancer.
Deep stromal invasion is an important pathological factor associated with the treatments and prognosis of cervical cancer patients. Accurate determination of deep stromal invasion before radical hysterectomy (RH) is of great value for early clinical treatment decision-making and improving the progno...
| Publicado en: | Journal of Digital Imaging Vol. 37; no. 1; pp. 230 - 247 |
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| Autores principales: | , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175966501&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175966501 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08971889 DOQ jtl: Journal of Digital Imaging issn: 08971889 maglogo: N pubinfo: dt: Feb2024 vid: 37 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 175966501 175966501 175966501 10.1007/s10278-023-00906-w 175966501 ppf: 230 ppct: 17 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Machine Learning-Based Multiparametric Magnetic Resonance Imaging Radiomics Model for Preoperative Predicting the Deep Stromal Invasion in Patients with Early Cervical Cancer. aug: au: Yan, Haowen Huang, Gaoting Yang, Zhihe Chen, Yirong Xiang, Zhiming affil: https://ror.org/05d5vvz89 The First Affiliated Hospital of Jinan University, 510632, Guangzhou, China sug: subj: Machine Learning Magnetic Resonance Imaging Methods Radiomics Connective Tissue Cells Pathology Cervix Neoplasms Diagnosis Evaluation Funding Source Cross Sectional Studies Human Female ROC Curve Confidence Intervals Analysis of Variance Chi Square Test Pearson's Correlation Coefficient Comparative Studies Sensitivity and Specificity Predictive Validity Linear Regression Multivariate Analysis Logistic Regression Statistical Significance Female ab: Deep stromal invasion is an important pathological factor associated with the treatments and prognosis of cervical cancer patients. Accurate determination of deep stromal invasion before radical hysterectomy (RH) is of great value for early clinical treatment decision-making and improving the prognosis of these patients. Machine learning is gradually applied in the construction of clinical models to improve the accuracy of clinical diagnosis or prediction, but whether machine learning can improve the preoperative diagnosis accuracy of deep stromal invasion in patients with cervical cancer was still unclear. This cross-sectional study was to construct three preoperative diagnostic models for deep stromal invasion in patients with early cervical cancer based on clinical, radiomics, and clinical combined radiomics data using the machine learning method. We enrolled 229 patients with early cervical cancer receiving RH combined with pelvic lymph node dissection (PLND). The least absolute shrinkage and selection operator (LASSO) and the fivefold cross-validation were applied to screen out radiomics features. Univariate and multivariate logistic regression analyses were applied to identify clinical predictors. All subjects were divided into the training set (n = 160) and testing set (n = 69) at a ratio of 7:3. Three light gradient boosting machine (LightGBM) models were constructed in the training set and verified in the testing set. The radiomics features were statistically different between deep stromal invasion < 1/3 group and deep stromal invasion ≥ 1/3 group. In the training set, the area under the curve (AUC) of the prediction model based on radiomics features was 0.951 (95% confidence interval (CI) 0.922–0.980), the AUC of the prediction model based on clinical predictors was 0.769 (95% CI 0.703–0.835), and the AUC of the prediction model based on radiomics features and clinical predictors was 0.969 (95% CI 0.947–0.990). The AUC of the prediction model based on radiomics features and clinical predictors was 0.914 (95% CI 0.848–0.980) in the testing set. The prediction model for deep stromal invasion in patients with early cervical cancer based on clinical and radiomics data exhibited good predictive performance with an AUC of 0.969, which might help the clinicians early identify patients with high risk of deep stromal invasion and provide timely interventions. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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