A 3D Sparse Autoencoder for Fully Automated Quality Control of Affine Registrations in Big Data Brain MRI Studies.

This paper presents a fully automated pipeline using a sparse convolutional autoencoder for quality control (QC) of affine registrations in large-scale T1-weighted (T1w) and T2-weighted (T2w) magnetic resonance imaging (MRI) studies. Here, a customized 3D convolutional encoder-decoder (autoencoder)...

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Publicado en:Journal of Digital Imaging Vol. 37; no. 1; pp. 412 - 428
Autores principales: Thadikemalla, Venkata Sainath Gupta, Focke, Niels K., Tummala, Sudhakar
Formato: diagnostic images equations & formulas research tables/charts Journal Article
Publicado: Springer Nature Feb2024
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Feb2024
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      pub: Springer Nature
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        10.1007/s10278-023-00933-7
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          Thadikemalla, Venkata Sainath Gupta
          Focke, Niels K.
          Tummala, Sudhakar
        affil: Department of Electronics and Communication Engineering, Velagapudi Ramakrishna Siddhartha Engineering College, Vijayawada, Andhra Pradesh, India
      sug:
        subj:
          Diagnosis, Brain
          Magnetic Resonance Imaging Methods
          Quality Control (Technology)
          Data Analytics
          Autoencoder
          Human
          ROC Curve
          Descriptive Statistics
      ab: This paper presents a fully automated pipeline using a sparse convolutional autoencoder for quality control (QC) of affine registrations in large-scale T1-weighted (T1w) and T2-weighted (T2w) magnetic resonance imaging (MRI) studies. Here, a customized 3D convolutional encoder-decoder (autoencoder) framework is proposed and the network is trained in a fully unsupervised manner. For cross-validating the proposed model, we used 1000 correctly aligned MRI images of the human connectome project young adult (HCP-YA) dataset. We proposed that the quality of the registration is proportional to the reconstruction error of the autoencoder. Further, to make this method applicable to unseen datasets, we have proposed dataset-specific optimal threshold calculation (using the reconstruction error) from ROC analysis that requires a subset of the correctly aligned and artificially generated misalignments specific to that dataset. The calculated optimum threshold is used for testing the quality of remaining affine registrations from the corresponding datasets. The proposed framework was tested on four unseen datasets from autism brain imaging data exchange (ABIDE I, 215 subjects), information eXtraction from images (IXI, 577 subjects), Open Access Series of Imaging Studies (OASIS4, 646 subjects), and "Food and Brain" study (77 subjects). The framework has achieved excellent performance for T1w and T2w affine registrations with an accuracy of 100% for HCP-YA. Further, we evaluated the generality of the model on four unseen datasets and obtained accuracies of 81.81% for ABIDE I (only T1w), 93.45% (T1w) and 81.75% (T2w) for OASIS4, and 92.59% for "Food and Brain" study (only T1w) and in the range 88–97% for IXI (for both T1w and T2w and stratified concerning scanner vendor and magnetic field strengths). Moreover, the real failures from "Food and Brain" and OASIS4 datasets were detected with sensitivities of 100% and 80% for T1w and T2w, respectively. In addition, AUCs of > 0.88 in all scenarios were obtained during threshold calculation on the four test sets.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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