Levels of neuronal pentraxin 2 in plasma is associated with cognitive function in patients with schizophrenia.
Rationale: The precise diagnosis and treatment of cognitive impairment remains a major challenge in the field of schizophrenia (SCZ) research. Synaptic dysfunction and loss are thought to be closely related to the occurrence and development of SCZ and may be involved in cognitive dysfunction. Object...
| Publicado en: | Psychopharmacology Vol. 241; no. 4; pp. 865 - 875 |
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| Autores principales: | , , , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175981394&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175981394 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Apr2024 vid: 241 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 175981394 174656970 10.1007/s00213-023-06515-3 175981394 ppf: 865 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Levels of neuronal pentraxin 2 in plasma is associated with cognitive function in patients with schizophrenia. aug: au: Zhou, Jiahui Li, Xiaojing Wang, Xiujuan Yang, Yongfeng Nai, Aoyang Shi, Han Zhao, Jingyuan Zhang, Jianhong Ding, Shuang Han, Yong Liu, Qing Zhang, Luwen Chen, Tengfei Liu, Bing Yue, Weihua Lv, Luxian Li, Wenqiang affil: Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China sug: ab: Rationale: The precise diagnosis and treatment of cognitive impairment remains a major challenge in the field of schizophrenia (SCZ) research. Synaptic dysfunction and loss are thought to be closely related to the occurrence and development of SCZ and may be involved in cognitive dysfunction. Objectives: The purpose of this study was to investigate whether neuronal pentraxins (NPTXs) plays a role in the etiology of SCZ and provide evidence of its possible therapeutic value a new target for drug development. Methods: We recruited 275 participants, of whom 148 were SCZ from psychiatric hospital and 127 healthy control (HC) subjects from communities. Plasma concentrations of NPTXs were measured in HC and SCZ at baseline and after 8 weeks of antipsychotic treatment. The MATRICS Cognitive Consensus Battery was used to evaluate cognitive function. Furthermore, the brain is parcellated into 246 subregions using the Brainnetome atlas, and we extracted regional white matter volumes from magnetic resonance images of the SCZ groups. Results: Plasma NPTX2 levels were significantly lower in SCZ compared with HC subjects, but were significantly raised in SCZ after 8 weeks of antipsychotic treatment compared to baseline. In addition, baseline plasma NPTX2 levels were positively correlated with cognitive performance. Conclusions: These findings indicate that NPTX2 may reveal novel aspects of disease etiology and act as a promising target for new drug development. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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