A Randomized, Double-Blind, Placebo-Controlled Trial: Efficacy of Opuntia ficus - indica Prebiotic Supplementation in Subjects with Gut Dysbiosis.
Gut dysbiosis refers to an imbalance in gut microbiota composition and function. Opuntia ficus-indica extract has been shown to modulate gut microbiota by improving SCFA production in vivo and gastrointestinal discomfort (GD) in humans. The aim of this study was to demonstrate the efficacy of Odilia...
| Publicado en: | Nutrients Vol. 16; no. 5; pp. 586 - 609 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
MDPI
Mar2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175991488&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175991488 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Mar2024 vid: 16 iid: 5 pid: 97109 pub: MDPI artinfo: ui: 175991488 175991488 175991488 10.3390/nu16050586 175991488 ppf: 586 ppct: 23 formats: tig: atl: A Randomized, Double-Blind, Placebo-Controlled Trial: Efficacy of Opuntia ficus - indica Prebiotic Supplementation in Subjects with Gut Dysbiosis. aug: au: Mellai, Marta Allesina, Marta Edoardo, Benedetto Cascella, Federica Nobile, Vincenzo Spina, Amelia Amone, Fabio Zaccaria, Vincenzo Insolia, Violetta Perri, Anna Lofaro, Danilo Puoci, Francesco affil: Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy sug: subj: Gastrointestinal Diseases Drug Therapy Prebiotics Therapeutic Use Plant Extracts Therapeutic Use Dietary Supplements Therapeutic Use Drug Efficacy Plant Extracts Pharmacodynamics Inflammation Brain-Gut Axis Drug Effects Gut Microbiota Drug Effects Immunity Drug Effects Oxidative Stress Drug Effects Treatment Outcomes Human Male Female Sequence Analysis Randomized Controlled Trials Random Assignment Double-Blind Studies Descriptive Statistics Comparative Studies Placebo Effect Adult Genomics Funding Source Adult: 19-44 years Male Female ab: Gut dysbiosis refers to an imbalance in gut microbiota composition and function. Opuntia ficus-indica extract has been shown to modulate gut microbiota by improving SCFA production in vivo and gastrointestinal discomfort (GD) in humans. The aim of this study was to demonstrate the efficacy of OdiliaTM on gastrointestinal health by changing the microbial diversity of species involved in inflammation, immunity, oxidation, and the brain–gut–muscle axis. A randomized, double-blind clinical trial was conducted in 80 adults with gut dysbiosis. The intervention consisted of a 300 mg daily intake of OdiliaTM (n = 40) or maltodextrin as a placebo (n = 40), administered for 8 weeks. Intervention effect was evaluated using 16S metagenomics and GIQLI/GSAS scores at baseline, at 4 and 8 weeks. Eight weeks of OdiliaTM supplementation positively modulates gut microbiota composition with a significant reduction in the Firmicutes to Bacteroidetes ratio (p = 0.0012). Relative abundances of beneficial bacteria (Bacteroides and Clostridium_XIVa) were significantly increased (p < 0.001), in contrast to a significant reduction in pro-inflammatory bacteria (p < 0.001). Accordingly, GIQLI and GSAS scores revealed successful improvement in GD. OdiliaTM may represent an effective and well-tolerated treatment in subjects with gut dysbiosis. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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