Baclofen in the treatment of alcohol use disorder: tailored doses matter.
Aims To address the question of tailored baclofen prescribing in alcohol use disorder (AUD) in relation to dose-dependent efficacy and the potential danger of high doses and to provide suggestions for the use of high doses of baclofen in the treatment of AUD. The context is the approvement in France...
| Publicado en: | Alcohol & Alcoholism Vol. 59; no. 2; pp. 1 - 11 |
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| Autores principales: | , |
| Formato: | review Journal Article |
| Publicado: |
Oxford University Press / USA
Mar2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=176004715&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 176004715 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Mar2024 vid: 59 iid: 2 pid: 622 pub: Oxford University Press / USA artinfo: ui: 176004715 176004715 176004715 10.1093/alcalc/agad090 176004715 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Baclofen in the treatment of alcohol use disorder: tailored doses matter. aug: au: Beaurepaire, Renaud de Jaury, Philippe affil: Renaud de Beaurepaire, GH Paul-Guiraud , 54 Avenue de La République, 94806 Villejuif , France sug: subj: Alcoholism Drug Therapy Substance Use Disorders Drug Therapy Baclofen Therapeutic Use Baclofen Adverse Effects Patient Education Baclofen Administration and Dosage Prescribing Patterns Treatment Outcomes Patient Safety Anxiety Affective Disorders Psychotic Disorders Seizures Sleep Disorders ab: Aims To address the question of tailored baclofen prescribing in alcohol use disorder (AUD) in relation to dose-dependent efficacy and the potential danger of high doses and to provide suggestions for the use of high doses of baclofen in the treatment of AUD. The context is the approvement in France of baclofen in the treatment of AUD without dose limitation, making French physicians, who usually prescribe baclofen in a tailored manner, often use high or very high doses. Methods A narrative review of the results of randomized controlled trials (RCTs) and observational studies that used tailored baclofen prescribing and of the severe adverse effects of baclofen that have been reported in the literature. Results The results show that RCTs using tailored doses of baclofen in AUD are not completely demonstrative, though they are encouraging according to certain meta-analyses, while observational studies that used tailored doses constantly show a good effectiveness of baclofen treatment. The results suggest that many severe adverse effects of baclofen could be related to a nonrespect by physicians of prescription rules and appropriate treatment monitoring. Conclusions The use of tailored doses shows that the dose required to suppress cravings is highly variable, low or high, depending on each case. Analysis of the circumstances in which severe adverse effects occur suggest that a careful monitoring of baclofen prescribing might prevent a large majority of severe adverse effects. We propose that the education of the patients and the prescription skills, seriousness, and availability of the prescribing physicians are of major importance in the managing of tailored baclofen treatment of AUD. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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