Atrophy of the cholinergic regions advances from early to late mild cognitive impairment.
Purpose: We investigated the volumetric changes in the components of the cholinergic pathway for patients with early mild cognitive impairment (EMCI) and those with late mild cognitive impairment (LMCI). The effect of patients' apolipoprotein 4 (APOE-ε4) allele status on the structural changes were...
| Publicado en: | Neuroradiology Vol. 66; no. 4; pp. 543 - 557 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=176032322&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 176032322 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Apr2024 vid: 66 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 176032322 174867596 176032322 176032322 10.1007/s00234-024-03290-6 176032322 ppf: 543 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Atrophy of the cholinergic regions advances from early to late mild cognitive impairment. aug: au: Lai, Ying-Liang Larry Hsu, Fei-Ting Yeh, Shu-Yi Kuo, Yu-Tzu Lin, Hui-Hsien Lin, Yi-Chun Kuo, Li-Wei Chen, Cheng-Yu Liu, Hua-Shan affil: Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taipei, Taiwan sug: subj: Mild Cognitive Impairment Pathology Atrophy Alzheimer's Disease Pathology Apolipoproteins Cholinergic Agents Magnetic Resonance Imaging Methods Brain Pathology Human Female Cognitive Aging Neuroradiography Biological Markers Prospective Studies Data Analysis Software Magnetic Resonance Imaging Analysis of Covariance Analysis of Variance Descriptive Statistics Funding Source Chi Square Test Female ab: Purpose: We investigated the volumetric changes in the components of the cholinergic pathway for patients with early mild cognitive impairment (EMCI) and those with late mild cognitive impairment (LMCI). The effect of patients' apolipoprotein 4 (APOE-ε4) allele status on the structural changes were analyzed. Methods: Structural magnetic resonance imaging data were collected. Patients' demographic information, plasma data, and validated global cognitive composite scores were included. Relevant features were extracted for constructing machine learning models to differentiate between EMCI (n = 312) and LMCI (n = 541) and predict patients' neurocognitive function. The data were analyzed primarily through one-way analysis of variance and two-way analysis of covariance. Results: Considerable differences were observed in cholinergic structural changes between patients with EMCI and LMCI. Cholinergic atrophy was more prominent in the LMCI cohort than in the EMCI cohort (P < 0.05 family-wise error corrected). APOE-ε4 differentially affected cholinergic atrophy in the LMCI and EMCI cohorts. For LMCI cohort, APOE-ε4 carriers exhibited increased brain atrophy (left amygdala: P = 0.001; right amygdala: P = 0.006, and right Ch123, P = 0.032). EMCI and LCMI patients showed distinctive associations of gray matter volumes in cholinergic regions with executive (R2 = 0.063 and 0.030 for EMCI and LMCI, respectively) and language (R2 = 0.095 and 0.042 for EMCI and LMCI, respectively) function. Conclusions: Our data confirmed significant cholinergic atrophy differences between early and late stages of mild cognitive impairment. The impact of the APOE-ε4 allele on cholinergic atrophy varied between the LMCI and EMCI groups. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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