Investigation of the effects of Gamma Knife radiosurgery on optic pathways using diffusion tensor MRI within the first year after treatment.
Purpose: To investigate the radiation-induced effects of Gamma Knife radiosurgery (GKRS) for sellar-parasellar tumors on optic pathways using DTI parameters within the first year after treatment. Methods: Twenty-five patients with sellar-parasellar tumors underwent MRI before and 3 months after GKRS...
| Publicado en: | Neuroradiology Vol. 66; no. 4; pp. 609 - 621 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=176032326&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 176032326 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Apr2024 vid: 66 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 176032326 175479621 176032326 176032326 10.1007/s00234-024-03296-0 176032326 ppf: 609 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Investigation of the effects of Gamma Knife radiosurgery on optic pathways using diffusion tensor MRI within the first year after treatment. aug: au: Yazol, Merve Ozer, Halil Asfuroglu, Berrak Barutcu Kurt, Gökhan Emmez, Ömer Hakan Öner, Ali Yusuf affil: https://ror.org/054xkpr46 Department of Radiology, Gazi University School of Medicine, 06560, Ankara, Turkey sug: subj: Radiosurgery Adverse Effects Optic Nerve Radiation Effects Treatment Outcomes Magnetic Resonance Imaging Methods Brain Neoplasms Surgery Human Male Female Adult Middle Age Aged Pretest-Posttest Design Comparative Studies White Matter Injuries Descriptive Statistics Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: To investigate the radiation-induced effects of Gamma Knife radiosurgery (GKRS) for sellar-parasellar tumors on optic pathways using DTI parameters within the first year after treatment. Methods: Twenty-five patients with sellar-parasellar tumors underwent MRI before and 3 months after GKRS, including T1WI, DTI, T2WI. Moreover, 21 patients underwent follow-up DTI 6–8 months after radiosurgery. ROIs were set on optic nerves, optic radiations, and control localizations; DTI parameters for each were calculated. Pre- and post-radiosurgery differences in DTI values were statistically compared and assessed with respect to tumor size changes. Results: Following GKRS, DTI parameters, notably ADC, FA, and RD, showed statistically significant changes in optic nerves and anterior optic radiations. DTI changes were more significant in the group of cases with tumor shrinkage. In this group, DTI of the anterior optic radiations further deteriorated 3 months post-GKRS, whereas acute changes in DTI parameters of the optic nerves resolved within 6–8 months. DTI of central and posterior optic radiations did not differ significantly following radiosurgery; 6–8 months after radiosurgery, visual function was stable in 14 (56%) patients and improved in 11 (44%), showing no correlation with tumor size changes or DTI parameters. Conclusion: White Matter (WM) injury in the optic pathways can be induced by Gamma Knife radiosurgery targeted to sellar and parasellar tumors. Following GKRS, microstructural abnormalities occurred in the optic radiations as well as the optic nerves within the first post-treatment year. Our findings could support modifications to radiosurgical treatment strategies to minimize the risk of permanent WM injury. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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