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Immediate effect of recurrent laryngeal nerve stimulation in patients with idiopathic unilateral vocal fold paralysis.

There is a lack of effective treatment for idiopathic unilateral vocal fold paralysis (IUVFP). A better phonation was reported by patients after laryngeal nerve stimulation during our clinical examination. This study aims to investigate immediate effect of recurrent laryngeal nerve (RLN) stimulation...

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Published in:Acta Oto-Laryngologica Vol. 144; no. 1; pp. 65 - 71
Main Authors: Yan, Jing, Hou, Jin, Zhang, Huihui, Yang, Xinyi, Sheng, Ying, Du, Xiaoying, Kong, Demin, Wang, Zhenghui, Ren, Xiaoyong, Wu, Liang
Format: equations & formulas pictorial research tables/charts Journal Article
Published: Taylor & Francis Ltd Jan2024
Online Access:View this record in EBSCOhost
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      dt: Jan2024
      vid: 144
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      pub: Taylor & Francis Ltd
      place: Philadelphia, Pennsylvania
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        10.1080/00016489.2024.2306961
        176072850
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        atl: Immediate effect of recurrent laryngeal nerve stimulation in patients with idiopathic unilateral vocal fold paralysis.
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        au:
          Yan, Jing
          Hou, Jin
          Zhang, Huihui
          Yang, Xinyi
          Sheng, Ying
          Du, Xiaoying
          Kong, Demin
          Wang, Zhenghui
          Ren, Xiaoyong
          Wu, Liang
        affil: Department of Otorhinolaryngology Head and Neck Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China
      sug:
        subj:
          Vocal Cord Paralysis Physiopathology
          Vocal Cord Paralysis Therapy
          Recurrent Laryngeal Nerve
          Electrical Stimulation, Neuromuscular
          Treatment Outcomes
          Voice Quality
          Vocal Cords Physiology
          Human
          Male
          Female
          Laryngoscopy
          Acoustics
          Voice Perception
          Descriptive Statistics
          Glottis Physiology
          Funding Source
          Voice Disorders
          Mann-Whitney U Test
          Pilot Studies
          Male
          Female
      ab:
        There is a lack of effective treatment for idiopathic unilateral vocal fold paralysis (IUVFP). A better phonation was reported by patients after laryngeal nerve stimulation during our clinical examination. This study aims to investigate immediate effect of recurrent laryngeal nerve (RLN) stimulation on phonation in patients with IUVFP. Sixty-two patients with clinically identified IUVFP underwent RLN stimulation with needle electrodes. Laryngoscopy, acoustic analysis, and voice perception assessment were performed for quantitative comparison of vocal function and voice quality before and after the intervention. Laryngoscopic images showed a larger motion range of the paralyzed vocal fold (p <.01) and better glottal closure (p <.01) after RLN stimulation. Acoustic analysis revealed that the dysphonia severity index increased significantly (p <.01) while the jitter and shimmer decreased after the intervention (p <.05). According to perceptual evaluation, RLN stimulation significantly increased RBH grades in patients with IUVFP (p <.01). Furthermore, the improvement in voice perception had a moderate positive correlation with the decrease in the glottal closure. This study shows a short-term improvement of phonation in IUVFP patients after RLN stimulation, which provides proof-of-concept for trialing a controlled delivery of RLN stimulation and assessing durability of any observed responses.
        特发性单侧声带麻痹(IUVFP)缺乏有效的治疗方法。据患者报告, 在我们的临床检查时, 喉神经刺激后发音更好。 本研究旨在探讨返喉神经(RLN)刺激对IUVFP患者发音的即时效果。 62例临床确诊的IUVFP患者接受针状电极RLN刺激。进行喉镜检查、声学分析和声音感知评估, 对干预前后的发声功能和声音质量进行定量比较。 喉镜图像显示, RLN刺激后麻痹声带的运动范围较大(p < 0.01), 声门闭合更好(p < 0.01)。声学分析显示, 干预后发音困难严重程度指数显著增加(p < 0.01), 而抖动和微光减少(p < 0.05)。根据感知评估, RLN刺激显著提高了IUVFP患者的RBH等级(p < 0.01)。此外, 声音感知的改善与声门闭合减少呈中度正相关。 本研究显示, IUVFP患者经RLN刺激后发音有短期改善, 这为试验RLN刺激的控制性递送和评估任何所观察到的反应的持久性提供了概念证明。
      pubtype: Academic Journal
      doctype:
        equations & formulas
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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