COVID-19 disease among children and young adults enrolled in the North American Pediatric Renal Trials and Collaborative Studies registry.
Background: Coronavirus disease of 2019 (COVID-19) has disproportionately affected adults with kidney disease. Data regarding outcomes among children with kidney disease are limited. The North American Pediatric Renal Trials Collaborative Studies Registry (NAPRTCS) has followed children with chronic...
| Publicado en: | Pediatric Nephrology Vol. 39; no. 5; pp. 1459 - 1469 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=176081530&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 176081530 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: May2024 vid: 39 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 176081530 174151194 176081530 176081530 10.1007/s00467-023-06241-0 176081530 ppf: 1459 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: COVID-19 disease among children and young adults enrolled in the North American Pediatric Renal Trials and Collaborative Studies registry. aug: au: Twichell, Sarah Ashoor, Isa Boynton, Sara Dharnidharka, Vikas Kizilbash, Sarah Erez, Daniella Levy Smith, Jodi Somers, Michael Chua, Annabelle Hooper, David Barletta, Gina-Marie Belsha, Craig Brakeman, Paul Verghese, Priya Atkinson, Meredith Warady, Bradley Bartosh, Sharon Swinford, Rita Zahr, Rima Blydt-Hansen, Tom affil: https://ror.org/0155zta11 Department of Pediatrics, The University of Vermont Robert Larner College of Medicine, Burlington, VT, USA sug: subj: COVID-19 Pandemic Psychosocial Factors COVID-19 Pandemic Psychosocial Factors Clinical Trials Kidney Failure, Chronic Dialysis Kidney Transplantation Registries, Disease Research Subjects Psychosocial Factors Human North America Female Male Child Adolescence Young Adult Adult Retrospective Design Prospective Studies North Americans Hospitalization Risk Assessment Outcomes (Health Care) T-Tests Chi Square Test Univariate Statistics Logistic Regression Descriptive Statistics Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Female Male ab: Background: Coronavirus disease of 2019 (COVID-19) has disproportionately affected adults with kidney disease. Data regarding outcomes among children with kidney disease are limited. The North American Pediatric Renal Trials Collaborative Studies Registry (NAPRTCS) has followed children with chronic kidney disease (CKD) since 1987 at 87 participating centers. This study aimed to evaluate the impact of COVID-19 among participants enrolled in the three arms of the registry: CKD, dialysis, and transplant. Methods: This was a retrospective cohort study of COVID-19 among participants in the NAPRTCS CKD, dialysis, and transplant registries from 2020 to 2022. Where appropriate, t-tests, chi-square analyses, and univariate logistic regression were used to evaluate the data. Results: The cohort included 1505 NAPRTCS participants with recent data entry; 260 (17%) had documented COVID-19. Infections occurred in all three registry arms, namely, 10% (n = 29) in CKD, 11% (n = 67) in dialysis, and 26% (n = 164) in transplant. The majority of participants (75%) were symptomatic. Hospitalizations occurred in 17% (n = 5) of participants with CKD, 27% (n = 18) maintenance dialysis participants, and 26% (n = 43) of transplant participants. Fourteen percent (n = 4) of CKD participants and 10% (n = 17) of transplant participants developed acute kidney injury (AKI), and a total of eight participants (one CKD, seven transplant) required dialysis initiation. Among transplant participants with moderate to severe illness, 40–43% developed AKI and 29–40% required acute dialysis. There were no reported deaths. Conclusions: COVID-19 was documented in 17% of active NAPRTCS participants. While there was no documented mortality, the majority of participants were symptomatic, and a quarter required hospitalization. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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