Test-Retest Reliability of Repetitive Ocular Vestibular Evoked Myogenic Potentials in Myasthenia Gravis Patients and Healthy Control Subjects.
Purpose: Repetitive ocular vestibular evoked myogenic potentials (ROVEMP) are a novel diagnostic test to quantify neuromuscular transmission deficits in extraocular muscles in myasthenia gravis. We aimed to investigate the test-retest reliability of the ROVEMP and the effect of amplitude and age.Met...
| Publicado en: | Journal of Clinical Neurophysiology Vol. 41; no. 3; pp. 265 - 271 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Mar2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=176113449&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 176113449 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07360258 8CL jtl: Journal of Clinical Neurophysiology issn: 07360258 maglogo: N pubinfo: dt: Mar2023 vid: 41 iid: 3 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 176113449 176113449 NLM36413652 10.1097/WNP.0000000000000956 NLM36413652 176113449 ppf: 265 ppct: 6 formats: tig: atl: Test-Retest Reliability of Repetitive Ocular Vestibular Evoked Myogenic Potentials in Myasthenia Gravis Patients and Healthy Control Subjects. aug: au: Keene, Kevin R. Bongers, Julia de Meel, Robert H. P. Venhovens, Jeroen Verschuuren, Jan J. G. M. Tannemaat, Martijn R. affil: Department of Neurology and Clinical Neurophysiology, Leiden University Medical Center, Leiden, the Netherlands sug: ab: Purpose: Repetitive ocular vestibular evoked myogenic potentials (ROVEMP) are a novel diagnostic test to quantify neuromuscular transmission deficits in extraocular muscles in myasthenia gravis. We aimed to investigate the test-retest reliability of the ROVEMP and the effect of amplitude and age.Methods: We performed the ROVEMP test twice in 19 patients with myasthenia gravis (52.7 ± 19.8 years) and in 15 healthy control subjects (46.5 ± 16 years). The Bland-Altman level of agreement was determined. The relationship between test-retest reliability and signal quality, participant age and signal amplitude was studied.Results: Limits of agreement were from -179.9 to 139.3 in myasthenia gravis patients and from -56.9 to 89.5 in healthy control subjects. Difference between measurements correlated with signal amplitude (r = -0.50, P < 0.001). Combining the primary cohort with previously published data from 114 subjects, we found a significant negative correlation between age and reference amplitude (r = -0.163, P = 0.045).Conclusions: This study shows that in our hands, the test-retest reliability of the ROVEMP is not optimal. Measurements with higher reference amplitude had a better quality, higher reproducibility, and increased diagnostic yield. We caution against the use of ROVEMP measurements of lower amplitude in clinical practice. In addition, given the correlation between age and amplitude, age matching of healthy control subjects and patients is essential in future studies. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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