Infiltration to infection: key virulence players of Helicobacter pylori pathogenicity.
Purpose: This study aims to comprehensively review the multifaceted factors underlying the successful colonization and infection process of Helicobacter pylori (H. pylori), a prominent Gram-negative pathogen in humans. The focus is on elucidating the functions, mechanisms, genetic regulation, and po...
| Publicado en: | Infection Vol. 52; no. 2; pp. 345 - 385 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=176180910&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 176180910 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Apr2024 vid: 52 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 176180910 174999659 176180910 176180910 10.1007/s15010-023-02159-9 176180910 ppf: 345 ppct: 40 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Infiltration to infection: key virulence players of Helicobacter pylori pathogenicity. aug: au: Bhattacharjee, Arghyadeep Sahoo, Om Saswat Sarkar, Ahana Bhattacharya, Saurabh Chowdhury, Rukhsana Kar, Samarjit Mukherjee, Oindrilla affil: Department of Biotechnology, National Institute of Technology Durgapur, 713209, Durgapur, West Bengal, India sug: subj: Helicobacter Infections Pathology Helicobacter Pylori Virulence Bacterial Colonization Genetics, Microbial Human Male Female Meta Analysis Peptic Ulcer Microbiology Genotype Gram-Negative Bacterial Infections Bacterial Proteins Biochemical Phenomena Male Female ab: Purpose: This study aims to comprehensively review the multifaceted factors underlying the successful colonization and infection process of Helicobacter pylori (H. pylori), a prominent Gram-negative pathogen in humans. The focus is on elucidating the functions, mechanisms, genetic regulation, and potential cross-interactions of these elements. Methods: Employing a literature review approach, this study examines the intricate interactions between H. pylori and its host. It delves into virulence factors like VacA, CagA, DupA, Urease, along with phase variable genes, such as babA, babC, hopZ, etc., giving insights about the bacterial perspective of the infection The association of these factors with the infection has also been added in the form of statistical data via Funnel and Forest plots, citing the potential of the virulence and also adding an aspect of geographical biasness to the virulence factors. The biochemical characteristics and clinical relevance of these factors and their effects on host cells are individually examined, both comprehensively and statistically. Results: H. pylori is a Gram-negative, spiral bacterium that successfully colonises the stomach of more than half of the world's population, causing peptic ulcers, gastric cancer, MALT lymphoma, and other gastro-duodenal disorders. The clinical outcomes of H. pylori infection are influenced by a complex interplay between virulence factors and phase variable genes produced by the infecting strain and the host genetic background. A meta-analysis of the prevalence of all the major virulence factors has also been appended. Conclusion: This study illuminates the diverse elements contributing to H. pylori's colonization and infection. The interplay between virulence factors, phase variable genes, and host genetics determines the outcome of the infection. Despite biochemical insights into many factors, their comprehensive regulation remains an understudied area. By offering a panoramic view of these factors and their functions, this study enhances understanding of the bacterium's perspective, i.e. H. pylori's journey from infiltration to successful establishment within the host's stomach. pubtype: Academic Journal doctype: meta analysis pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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