Default mode network aberrance in subjects of alcohol and opioid use disorders during working memory task: An exploratory EEG microstates study.
Background: Aberrance in switching from default mode network (DMN) to fronto-parietal network (FPN) is proposed to underlie working memory deficits in subjects with substance use disorders, which can be studied using neuro-imaging techniques during cognitive tasks. The current study used EEG to inve...
| Publicado en: | Indian Journal of Psychiatry Vol. 66; no. 3; pp. 272 - 280 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wolters Kluwer India Pvt Ltd
Mar2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=176209465&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 176209465 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00195545 GDJ jtl: Indian Journal of Psychiatry issn: 00195545 maglogo: N pubinfo: dt: Mar2024 vid: 66 iid: 3 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 176209465 176209465 176209465 10.4103/indianjpsychiatry.indianjpsychiatry_930_23 176209465 ppf: 272 ppct: 8 formats: tig: atl: Default mode network aberrance in subjects of alcohol and opioid use disorders during working memory task: An exploratory EEG microstates study. aug: au: Dastidar, Shaon Ghosh Leon, Chaithanya Pegwal, Nishi Balhara, Yatan Pal Singh M., Suriya Prakash Tayade, Prashant Sharma, Ratna Kaur, Simran affil: Stress and Cognitive Electroimaging Laboratory, Department of Physiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi sug: subj: Substance Use Disorders Alcoholism Analgesics, Opioid Adverse Effects Memory Task Performance and Analysis Large-Scale Brain Networks Electroencephalography Human Descriptive Statistics Data Analysis Software Mann-Whitney U Test One-Way Analysis of Variance Post Hoc Analysis Cross Sectional Studies Nonexperimental Studies Male Female Young Adult Adult Funding Source Exploratory Research Adult: 19-44 years Male Female ab: Background: Aberrance in switching from default mode network (DMN) to fronto-parietal network (FPN) is proposed to underlie working memory deficits in subjects with substance use disorders, which can be studied using neuro-imaging techniques during cognitive tasks. The current study used EEG to investigate pre-stimulus microstates during the performance of Sternberg's working memory task in subjects with substance use disorders. Methods: 128-channel EEG was acquired and processed in ten age and gender-matched subjects, each with alcohol use disorder, opioid use disorder, and controls while they performed Sternberg's task. Behavioral parameters, pre-stimulus EEG microstate, and underlying sources were analyzed and compared between subjects with substance use disorders and controls. Results: Both alcohol and opioid use disorder subjects had significantly lower accuracy (P < 0.01), while reaction times were significantly higher only in subjects of alcohol use disorder compared to controls (P < 0.01) and opioid use disorder (P < 0.01), reflecting working memory deficits of varying degrees in subjects with substance use disorders. Pre-stimulus EEG microstate revealed four topographic Maps 1-4: subjects of alcohol and opioid use disorder showing significantly lower mean duration of Map 3 (visual processing) and Map 2 (saliency and DMN switching), respectively, compared to controls (P < 0.05). Conclusion: Reduced mean durations in Map 3 and 2 in subjects of alcohol and opioid use disorder can underlie their poorer performance in Sternberg's task. Furthermore, cortical sources revealed higher activity in both groups of substance use disorders in the parahippocampal gyrus- a hub of DMN; superior and middle temporal gyri associated with impulsivity; and insula that maintains balance between executive reflective system and impulsive system. EEG microstates can be used to envisage neural underpinnings implicated for working memory deficits in subjects of alcohol and opioid use disorders, reflected by aberrant switching between neural networks and information processing mechanisms. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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