Clinical efficacy of crushed prednisolone and hydrocolloid powder in the primary treatment of peristomal pyoderma gangrenosum and correlation to in vitro drug release data.
We evaluated the primary application of crushed prednisolone combined with hydrocolloid powder for clinically diagnosed peristomal pyoderma gangrenosum (PPG). We present our data on this cohort and follow‐up of our previous patients. Of the 23 patients who were commenced on this regime, 18 healed (7...
| Publicado en: | International Wound Journal Vol. 21; no. 3; pp. 1 - 9 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Mar2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=176212953&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 176212953 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17424801 1725 jtl: International Wound Journal issn: 17424801 maglogo: Y pubinfo: dt: Mar2024 vid: 21 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 176212953 176212953 176212953 10.1111/iwj.14808 176212953 ppf: 1 ppct: 8 formats: tig: atl: Clinical efficacy of crushed prednisolone and hydrocolloid powder in the primary treatment of peristomal pyoderma gangrenosum and correlation to in vitro drug release data. aug: au: Pearson, Wendy Ann Prentice, David Andrew Lim, Lee Yong Gianoncelli, Olivia Hashiguchi, Alice Parisella, Tahlia Kate Ta, Jade Thien affil: Royal Perth Hospital, Perth Western Australia,, Australia sug: subj: Pyoderma Gangrenosum Drug Therapy Prednisolone Therapeutic Use Colloids Therapeutic Use Powders Drug Therapy, Combination Drug Efficacy Human In Vitro Studies Prospective Studies Funding Source Descriptive Statistics Treatment Outcomes Comorbidity ab: We evaluated the primary application of crushed prednisolone combined with hydrocolloid powder for clinically diagnosed peristomal pyoderma gangrenosum (PPG). We present our data on this cohort and follow‐up of our previous patients. Of the 23 patients who were commenced on this regime, 18 healed (78%). Twenty‐two patients commenced on this regime as the primary treatment for their PPG, and for one, it was a rescue remedy after failed conventional therapy. Four patients with significant medical comorbidities failed to heal and one had their stomal reversal surgery before being fully healed. The proposed treatment regime for PPG is demonstrated to be effective, inexpensive and able to be managed in the patient's usual home environment. In vitro drug release analysis was undertaken, and data are presented to provide further insights into the efficacy of this regime. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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