High-temporal resolution functional PET/MRI reveals coupling between human metabolic and hemodynamic brain response.
Purpose: Positron emission tomography (PET) provides precise molecular information on physiological processes, but its low temporal resolution is a major obstacle. Consequently, we characterized the metabolic response of the human brain to working memory performance using an optimized functional PET...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 51; no. 5; pp. 1310 - 1323 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=176221491&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 176221491 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Apr2024 vid: 51 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 176221491 174007898 10.1007/s00259-023-06542-4 176221491 ppf: 1310 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: High-temporal resolution functional PET/MRI reveals coupling between human metabolic and hemodynamic brain response. aug: au: Hahn, Andreas Reed, Murray B. Vraka, Chrysoula Godbersen, Godber M. Klug, Sebastian Komorowski, Arkadiusz Falb, Pia Nics, Lukas Traub-Weidinger, Tatjana Hacker, Marcus Lanzenberger, Rupert affil: https://ror.org/05n3x4p02 Department of Psychiatry and Psychotherapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria sug: ab: Purpose: Positron emission tomography (PET) provides precise molecular information on physiological processes, but its low temporal resolution is a major obstacle. Consequently, we characterized the metabolic response of the human brain to working memory performance using an optimized functional PET (fPET) framework at a temporal resolution of 3 s. Methods: Thirty-five healthy volunteers underwent fPET with [18F]FDG bolus plus constant infusion, 19 of those at a hybrid PET/MRI scanner. During the scan, an n-back working memory paradigm was completed. fPET data were reconstructed to 3 s temporal resolution and processed with a novel sliding window filter to increase signal to noise ratio. BOLD fMRI signals were acquired at 2 s. Results: Consistent with simulated kinetic modeling, we observed a constant increase in the [18F]FDG signal during task execution, followed by a rapid return to baseline after stimulation ceased. These task-specific changes were robustly observed in brain regions involved in working memory processing. The simultaneous acquisition of BOLD fMRI revealed that the temporal coupling between hemodynamic and metabolic signals in the primary motor cortex was related to individual behavioral performance during working memory. Furthermore, task-induced BOLD deactivations in the posteromedial default mode network were accompanied by distinct temporal patterns in glucose metabolism, which were dependent on the metabolic demands of the corresponding task-positive networks. Conclusions: In sum, the proposed approach enables the advancement from parallel to truly synchronized investigation of metabolic and hemodynamic responses during cognitive processing. This allows to capture unique information in the temporal domain, which is not accessible to conventional PET imaging. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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