Effectiveness of an Intensive, Functional, and Gamified Rehabilitation Program on Upper Limb Function in People With Stroke (EnteRtain): A Multicenter Randomized Clinical Trial.

Background1: Despite a growing interest in gaming rehabilitation for upper limb (UL) recovery post-stroke, studies investigating the effects of game-based rehabilitation incorporating functional games are lacking. Objective: To investigate the efficacy of an intensive, functional, gamified rehabilit...

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Publicado en:Neurorehabilitation & Neural Repair Vol. 38; no. 4; pp. 243 - 257
Autores principales: Ali, A. Sulfikar, Kumaran, D. Senthil, Unni, Amritha, Sardesai, Sanjukta, Prabhu, Vasudeva, Nirmal, Punitha, Pai, Aparna R., Guddattu, Vasudeva, Arumugam, Ashokan
Formato: research tables/charts randomized controlled trial Journal Article
Publicado: Sage Publications Inc. Apr2024
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Apr2024
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      pub: Sage Publications Inc.
      place: Thousand Oaks, California
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        atl: Effectiveness of an Intensive, Functional, and Gamified Rehabilitation Program on Upper Limb Function in People With Stroke (EnteRtain): A Multicenter Randomized Clinical Trial.
      aug:
        au:
          Ali, A. Sulfikar
          Kumaran, D. Senthil
          Unni, Amritha
          Sardesai, Sanjukta
          Prabhu, Vasudeva
          Nirmal, Punitha
          Pai, Aparna R.
          Guddattu, Vasudeva
          Arumugam, Ashokan
        affil: Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India
      sug:
        subj:
          Upper Extremity Pathology
          Stroke Rehabilitation
          Task Performance and Analysis
          Activities of Daily Living
          Quality of Life
          Motor Activity
          Physical Activity
          Therapeutic Exercise
          Gamification
          Human
          Male
          Female
          Adolescence
          Adult
          Middle Age
          Aged
          Randomized Controlled Trials
          Random Assignment
          Recovery
          Hemiplegia
          Single-Blind Studies
          Multicenter Studies
          Comparative Studies
          Regression
          Descriptive Statistics
          Confidence Intervals
          Funding Source
          Adolescent: 13-18 years
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Aged: 65+ years
          Male
          Female
      ab: Background1: Despite a growing interest in gaming rehabilitation for upper limb (UL) recovery post-stroke, studies investigating the effects of game-based rehabilitation incorporating functional games are lacking. Objective: To investigate the efficacy of an intensive, functional, gamified rehabilitation program compared to task-based training on UL motor function in acute/sub-acute stroke survivors. Methods: This randomized, multicenter, single-blind, clinical trial comprises 120 participants with unilateral stroke who were randomized to receive either gamified training (n = 64) using the ArmAble™ [experimental group (EG)] or task-based training (n = 56) in conjunction with conventional therapy for 2 hours per day, 6 days per week for 2 weeks, followed by UL rehabilitation for another 4 weeks at home. Primary outcomes evaluated by a blinded assessor included the Fugl-Meyer Assessment-Upper Extremity (FM-UE), and Action Research Arm Test (ARAT). Data were analyzed using a linear mixed-effect regression model. Results: The mean (standard deviation) age of the participants was 54.4 ± 11.7 years (78.1% men) in the EG and 57.7 ± 10.9 years (73.2% men) in the comparator group (CG). The median (interquartile range) time since stroke was 30.0 (54.0) days in the EG and 22.5 (45.0) days in the CG. Following the 2-week intervention, a statistically significant improvement was observed in the EG for the FM-UE [between-group mean differences (95% confidence interval): −3.9 (−6.5, −1.3); P =.003]; but not for the ARAT [−2.9 (−5.8, 0.0); P =.051]. Gains at 6 weeks were significantly greater in the EG for both FM-UE [−3.9 (−6.5, −1.3); P =.003]; and ARAT [−3.0 (−5.9, −0.0); P =.046]. Conclusion: Gamified rehabilitation using the ArmAble™ device has shown immediate and short-term improvement in UL function after acute/sub-acute stroke. Clinical Trials Registry Number: CTRI/2020/09/027651
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        randomized controlled trial
        Journal Article
      ougenre: Article
    language: English
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