Internet-Based Conversational Engagement Randomized Controlled Clinical Trial (I-CONECT) Among Socially Isolated Adults 75+ Years Old With Normal Cognition or Mild Cognitive Impairment: Topline Results.
Background and Objectives Social isolation is a risk factor for cognitive decline and dementia. We conducted a randomized controlled clinical trial (RCT) of enhanced social interactions, hypothesizing that conversational interactions can stimulate brain functions among socially isolated older adults...
| Publicado en: | Gerontologist Vol. 64; no. 4; pp. 1 - 15 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Oxford University Press / USA
Apr2024
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
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Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00169013 GET jtl: Gerontologist issn: 00169013 maglogo: N pubinfo: dt: Apr2024 vid: 64 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 176468947 10.1093/geront/gnad147 ppf: 1 ppct: 14 formats: tig: atl: Internet-Based Conversational Engagement Randomized Controlled Clinical Trial (I-CONECT) Among Socially Isolated Adults 75+ Years Old With Normal Cognition or Mild Cognitive Impairment: Topline Results. aug: au: Dodge, Hiroko H Yu, Kexin Wu, Chao-Yi Pruitt, Patrick J Asgari, Meysam Kaye, Jeffrey A Hampstead, Benjamin M Struble, Laura Potempa, Kathleen Lichtenberg, Peter Croff, Raina Albin, Roger L Silbert, Lisa C Team, the I-CONECT affil: Department of Neurology, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts , USA Oregon Center for Aging and Technology (ORCATECH), Oregon Health & Science University , Portland, Oregon , USA Layton Aging and Alzheimer's Disease Center, Department of Neurology, Oregon Health & Science University , Portland, Oregon , USA Department of Pediatrics, Oregon Health & Science University , Portland, Oregon , USA Michigan Alzheimer's Disease Center, Department of Neurology, University of Michigan , Ann Arbor, Michigan , USA Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan , Ann Arbor, Michigan , USA Department of Systems, Populations and Leadership, University of Michigan School of Nursing , Ann Arbor, Michigan , USA Institute of Gerontology and Department of Psychology, Wayne State University , Detroit, Michigan , USA GRECC & Neurology Service, VA Ann Arbor Healthcare System , Ann Arbor, Michigan , USA VA Portland Healthcare System , Portland, Oregon , USA su: Home care services Elder care Therapeutics Conversation Medical care Executive function Internet Randomized controlled trials Interpersonal relations Social isolation Cognition Social participation COVID-19 pandemic Well-being Old age Dementia prevention Mild cognitive impairment Research funding Statistical sampling Magnetic resonance imaging Descriptive statistics Experimental design Computers in medicine Research Comparative studies sug: subj: Home care services Elder care Therapeutics Conversation Medical care Executive function Internet Randomized controlled trials Interpersonal relations Social isolation Cognition Social participation COVID-19 pandemic Well-being Old age Continuing Care Retirement Communities Home Health Care Services Offices of All Other Miscellaneous Health Practitioners Offices of all other health practitioners Services for the Elderly and Persons with Disabilities Wired Telecommunications Carriers Internet Publishing and Broadcasting and Web Search Portals Diagnostic Imaging Centers Marketing Research and Public Opinion Polling Dementia prevention Mild cognitive impairment Research funding Statistical sampling Magnetic resonance imaging Descriptive statistics Experimental design Computers in medicine Research Comparative studies keyword: Alzheimer's disease and related dementias Behavioral intervention Cognitive reserve Semistructured conversations Social interactions Alzheimer's disease and related dementias Behavioral intervention Cognitive reserve Semistructured conversations Social interactions ab: Background and Objectives Social isolation is a risk factor for cognitive decline and dementia. We conducted a randomized controlled clinical trial (RCT) of enhanced social interactions, hypothesizing that conversational interactions can stimulate brain functions among socially isolated older adults without dementia. We report topline results of this multisite RCT (Internet-based conversational engagement clinical trial [I-CONECT]; NCT02871921). Research Design and Methods The experimental group received cognitively stimulating semistructured conversations with trained interviewers via internet/webcam 4 times per week for 6 months (induction) and twice per week for an additional 6 months (maintenance). The experimental and control groups both received weekly 10 minutes telephone check-ins. Protocol modifications were required due to the coronavirus disease 2019 pandemic. Results A total of 186 participants were randomized. After the induction period, the experimental group had higher global cognitive test scores (Montreal Cognitive Assessment [primary outcome]; 1.75 points [ p = .03]) compared with the control group. After induction, experimental group participants with normal cognition had higher language-based executive function (semantic fluency test [secondary outcome]; 2.56 points [ p = .03]). At the end of the maintenance period, the experimental group of mild cognitive impairment subjects had higher encoding function (Craft Story immediate recall test [secondary outcome]; 2.19 points [ p = .04]). Measure of emotional well-being improved in both control and experimental groups. Resting-state functional magnetic resonance imaging showed that the experimental group had increased connectivity within the dorsal attention network relative to the control group (p = .02), but the sample size was limited. Discussion and Implications Providing frequent stimulating conversational interactions via the internet could be an effective home-based dementia risk-reduction strategy against social isolation and cognitive decline. Clinical Trials Registration Number NCT02871921 pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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