Exploring the Mechanism of Echinatin against Cervical Cancer Based on Network Pharmacology.
Cervical cancer significantly impacts women's health due to its high mortality rate and increasing prevalence among younger individuals, thereby posing a severe threat. Echinatin is the primary active component of licorice in traditional Chinese medicine. However, studies on its use in cervical canc...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 2024; pp. 1 - 15 |
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| Autores principales: | , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
4/8/2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=176506788&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 176506788 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: 4/8/2024 vid: 2024 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 176506788 176506788 176506788 10.1155/2024/7008847 176506788 ppf: 1 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Exploring the Mechanism of Echinatin against Cervical Cancer Based on Network Pharmacology. aug: au: Chen, Hu Wang, Jinlei affil: Department of Gynecology, Shengli Oilfield Central Hospital, 31 Jinan Road, Dongying 257000, Shandong, China sug: subj: Licorice Therapeutic Use Flavonoids Therapeutic Use Drugs, Chinese Herbal Therapeutic Use Antineoplastic Agents Therapeutic Use Flavonoids Pharmacodynamics Drugs, Chinese Herbal Pharmacodynamics Antineoplastic Agents Pharmacodynamics Cervix Neoplasms Drug Therapy Network Pharmacology Women's Health Flavonoids Analysis Drugs, Chinese Herbal Analysis Human Molecular Structure Female Cervix Neoplasms Mortality Cervix Neoplasms Epidemiology Cell Cycle Drug Effects Apoptosis Drug Effects Cell Aging Drug Effects Signal Transduction Drug Effects Gene Expression Profiling Molecular Docking Simulation Blotting, Western Cell Proliferation Drug Effects Cell Movement Drug Effects Neoplasm Invasiveness Drug Therapy Female ab: Cervical cancer significantly impacts women's health due to its high mortality rate and increasing prevalence among younger individuals, thereby posing a severe threat. Echinatin is the primary active component of licorice in traditional Chinese medicine. However, studies on its use in cervical cancer treatment are limited. In our study, 198 targets of Echinatin were identified by some databases. Among these, 40 core targets related to cervical cancer were selected. Enrichment analyses revealed that Echinatin operated through genes associated with cell cycle, apoptosis, senescence, and various cancer-related signaling pathways. Differential expression of intersecting targets was verified in the GEO database, and molecular docking also indicated a strong binding capacity between active compounds and identified targets. Moreover, the results of western blot provided further evidence at the protein level. Echinatin hindered the proliferation, migration, and invasion of HeLa and SiHa cells while increasing their apoptosis. This study predicted the potential targets and beneficial effects of Echinatin in cervical cancer treatment, which provides a new avenue for further research into the molecular mechanisms underlying the role of Echinatin in cervical cancer treatment. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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