Dark Adaptometry and Optical Coherence Tomography Angiography in Huntington Disease.
Purpose: Huntington's Disease (HD) is a fully penetrant neurodegenerative disease leading to cognitive and motor disturbances. The retina may serve as a structural and functional extension of the central nervous system to identify biomarkers of HD using noninvasive imaging technology such as optical...
| Publicado en: | Journal of Ophthalmic & Vision Research Vol. 19; no. 1; pp. 18 - 25 |
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| Autores principales: | , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Knowledge E DMCC
Jan-Mar2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=176513356&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 176513356 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20082010 AY5S jtl: Journal of Ophthalmic & Vision Research issn: 20082010 maglogo: N pubinfo: dt: Jan-Mar2024 vid: 19 iid: 1 pid: 35682 pub: Knowledge E DMCC artinfo: ui: 176513356 176513356 176513356 10.18502/jovr.v19i1.15422 176513356 ppf: 18 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Dark Adaptometry and Optical Coherence Tomography Angiography in Huntington Disease. aug: au: Shah, Aaditya Fuller, Spencer Criswell, Susan Apte, Rajendra S. affil: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA sug: subj: Huntington's Disease Diagnosis Retina Physiology Tomography, Optical Coherence Methods Computed Tomography Angiography Methods Noninvasive Procedures Diagnostic Imaging Methods Human Adult Middle Age Aged Aged, 80 and Over Case Control Studies Neurodegenerative Diseases Complications Cognition Disorders Risk Factors Motor Skills Disorders Risk Factors Retina Radiography Data Collection Methods Descriptive Statistics Biological Markers Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over ab: Purpose: Huntington's Disease (HD) is a fully penetrant neurodegenerative disease leading to cognitive and motor disturbances. The retina may serve as a structural and functional extension of the central nervous system to identify biomarkers of HD using noninvasive imaging technology such as optical coherence tomography angiography (OCTA) and dark adaptometry. Methods: This case--control study included 12 HD participants (24 eyes) recruited from the Huntington's Disease Society of America Center of Excellence at Washington University in St. Louis along with 16 control participants (31 eyes). Disease-positive participants underwent imaging testing of retinal capillary density and foveal avascular zone utilizing OCTA along with dark adaptometry testing. Data were collected from November 2020 to February 2022. Results: Individuals with HD had a lower mean age-adjusted superficial foveal capillary density and a higher mean deep foveal capillary density compared to control subjects. There was no significant difference in the mean foveal avascular zone or in dark adaptometry testing between the two groups. Conclusion: This study suggests that changes in retinal biomarkers may exist in patients with HD and that additional investigations using multimodal techniques are warranted. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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