Analysis of atypical glandular cells in ThinPrep Pap smear and follow-up histopathology.
Diagnosing atypical glandular cells (AGC) is a significant challenge in cytomorphology. A retrospective study was undertaken to assess the prevalence of AGC and the subsequent histological outcomes over 5 years at a single institution. A total of 159,649 ThinPrep Pap tests, including 395 cases of AG...
| Publicado en: | Baylor University Medical Center Proceedings Vol. 37; no. 3; pp. 403 - 408 |
|---|---|
| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
May2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=176582725&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 176582725 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08998280 1XEP jtl: Baylor University Medical Center Proceedings issn: 08998280 maglogo: N pubinfo: dt: May2024 vid: 37 iid: 3 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 176582725 176163618 176582725 176582725 10.1080/08998280.2024.2324656 176582725 ppf: 403 ppct: 5 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Analysis of atypical glandular cells in ThinPrep Pap smear and follow-up histopathology. aug: au: Wang, Tengfei Hua, Yinan Liu, Lina Leng, Bing affil: Department of Pathology, Baylor Scott and White Health, Temple, Texas, USA sug: subj: Cervical Smears Methods Epithelial Cells Pathology Epithelial Cells Analysis Histology Cervix Diseases Diagnosis Human Female Retrospective Design Record Review Cytology Prevalence Health Facilities United States Mucous Membrane Squamous Intraepithelial Lesions Squamous Cell Carcinoma, Cervix Papillomavirus Infections Risk Factors Pathologists Job Experience Sensitivity and Specificity Descriptive Statistics Female ab: Diagnosing atypical glandular cells (AGC) is a significant challenge in cytomorphology. A retrospective study was undertaken to assess the prevalence of AGC and the subsequent histological outcomes over 5 years at a single institution. A total of 159,649 ThinPrep Pap tests, including 395 cases of AGC, were retrieved, of which 330 AGC cases had follow-up histopathology. Among these 330 cases, 43.9% were classified as AGC not otherwise specified, followed by AGC-endocervical cells at 33.3%. The most frequently observed histological findings at follow-up included CIN1 and benign mucosa with reactive changes, followed by high-grade squamous intraepithelial lesion and cervical squamous cell carcinoma. The overall 5-year insignificant AGC rate was 0.12%, and the overall 5-year significant AGC rate was 0.08%. Notably, 36.7% of AGC cases tested positive for high-risk human papillomavirus. Interestingly, the level of experience did not significantly impact the rates for significant or insignificant AGC diagnosis. However, senior cytopathologists had a higher AGC report rate compared to their junior peers. The AGC diagnostic rate at our institution falls within the range given by the College of American Pathologists. A significant number of cases had follow-up histologic results available, and the overall 5-year insignificant AGC rate was 0.12%. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|