A Monist Proposal: Against Integrative Pluralism About Protein Structure.
Mitchell & Gronenborn (2017) propose that we account for the presence of multiple models of protein structure, each produced in different contexts, through the framework of integrative pluralism. I argue that two interpretations of this framework are available, neither of which captures the relation...
| Published in: | Erkenntnis Vol. 89; no. 4; pp. 1711 - 1734 |
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| Format: | Article |
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Springer Nature
Apr2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=176583028&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 176583028 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 01650106 5KZ jtl: Erkenntnis issn: 01650106 maglogo: N pubinfo: dt: Apr2024 vid: 89 iid: 4 pid: 237 pub: Springer Nature artinfo: ui: 176583028 10.1007/s10670-022-00601-2 ppf: 1711 ppct: 23 formats: fmt: – @attributes: type: T – @attributes: type: P size: 1.1MB tig: atl: A Monist Proposal: Against Integrative Pluralism About Protein Structure. aug: au: Bolinska, Agnes affil: https://ror.org/02b6qw903 Department of Philosophy, University of South Carolina, 29208, Columbia, SC, USA su: Protein structure Protein models Protein folding Monism Pluralism sug: subj: Protein structure Protein models Protein folding Monism Pluralism ab: Mitchell & Gronenborn (2017) propose that we account for the presence of multiple models of protein structure, each produced in different contexts, through the framework of integrative pluralism. I argue that two interpretations of this framework are available, neither of which captures the relationship between a model and the protein structure it represents or between multiple models of protein structure. Further, it inclines us toward concluding prematurely that models of protein structure are right in their contexts and makes extrapolation of findings from one context to another seem unwarranted. Instead, protein structure determination ought to be understood as modestly monistic. There is one model for every protein in each physicochemical context, and models of the same protein produced in different contexts are compatible with one another. 'Integrating' multiple models amounts to extrapolating from one context to another; this is possible because the effect of context on protein folding is relatively weak and predictable. Modest monism better describes the practice of protein structure determination than integrative pluralism and enables greater attention to how context affects protein folding. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Erkenntnis is a copyright of Springer, 2024. All Rights Reserved. item: Erkenntnis holder: Springer Nature dt: @attributes: year: 2024 holdings: @attributes: islocal: N |
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