Construction of circular RNA‐based competing endogenous RNA network in colon cancer.
Circular RNAs (CircRNAs) are now under discussion as novel promising biomarkers for patients with various tumors. Our study aimed to identify circRNAs related to the progression of colon cancer and to further investigate their roles in the development of colon cancer base on The Cancer Genome Atlas...
| Publicado en: | Precision Medical Sciences Vol. 13; no. 1; pp. 52 - 63 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Mar2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=176586021&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 176586021 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 26422514 MBZV jtl: Precision Medical Sciences issn: 26422514 maglogo: N pubinfo: dt: Mar2024 vid: 13 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 176586021 176345003 176586021 176586021 10.1002/prm2.12127 176586021 ppf: 52 ppct: 11 formats: tig: atl: Construction of circular RNA‐based competing endogenous RNA network in colon cancer. aug: au: Gu, Zhengyu Wu, Weiyi Lu, Jinnan Shen, Jun affil: Department of Gastroenterology, Nanjing Red Cross Hospital, Nanjing, China sug: subj: RNA, Circular Colonic Neoplasms Tumor Markers, Biological Genome Cancer Patients Human Male Female Middle Age Aged Disease Progression Genes Correlational Studies Gene Expression Profiling MicroRNA Data Analysis Software Age Factors Sex Factors Neoplasm Staging Survival Sensitivity and Specificity Cell Line, Tumor Database Management Software Quantitative Studies T-Tests Comparative Studies Mann-Whitney U Test Kaplan-Meier Estimator Log-Rank Test Univariate Statistics Multivariate Analysis Cox Proportional Hazards Model Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Circular RNAs (CircRNAs) are now under discussion as novel promising biomarkers for patients with various tumors. Our study aimed to identify circRNAs related to the progression of colon cancer and to further investigate their roles in the development of colon cancer base on The Cancer Genome Atlas database. The competing endogenous RNA (ceRNA) network was constructed based on 4 circRNAs, 14 miRNAs, and 229 mRNAs. Meanwhile, three hub genes were identified via the protein protein interaction networks (PPI) network. It should be noted that only RUNX1 targeted by circ‐0084615 and mir‐330‐3p was confirmed as a survival‐related gene. Further analyses indicated the possible function of RUNX1 in colon progression, such as angiogenesis, epithelial–mesenchymal transition, hedgehog signaling and so on. Further investigations were conducted into the correlation between RUNX1 expression profiles and immune cells. Finally, we validated the expression of the circ‐0084615/mir‐330‐3p/RUNX1 axis in clinical specimens. In conclusion, we constructed ceRNA network and revealed that the circ‐0084615/mir‐330‐3p/RUNX1 axis serves as a critical role in colon cancer. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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