Safety, Tolerability, and Pharmacodynamics of the ADAMTS‐5 Nanobody M6495: Two Phase 1, Single‐Center, Double‐Blind, Randomized, Placebo‐Controlled Studies in Healthy Subjects and Patients With Osteoarthritis.

Objective: To assess the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple injections of M6495, a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS‐5) nanobody, in healthy volunteers and patients with osteoarthritis. Methods: Two randomized, placebo...

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Published in:	ACR Open Rheumatology Vol. 6; no. 4; pp. 205 - 214
Main Authors:	Bihlet, Asger Reinstrup, Balchen, Torben, Goteti, Kosalaram, Sonne, Jesper, Ladel, Christoph, Karsdal, Morten Asser, Ona, Victor, Moreau, Flavie, Waterhouse, Roseann, Bay‐Jensen, Anne‐Christine, Guehring, Hans
Format:	research tables/charts randomized controlled trial Journal Article
Published:	Wiley-Blackwell Apr2024
Online Access:	View this record in EBSCOhost