Case series of retinal vein occlusions showing early recovery using oral l -methylfolate.
This case series describes the aggregate rate of recovery in five consecutive subjects (six eyes) with retinal vein occlusion (RVO) who received l -methylfolate and other vitamins via Ocufolin®, a medical food. Subjects were followed for 10–33 months by a single ophthalmologist. Ocufolin® was prescr...
| Publicado en: | Therapeutic Advances in Ophthalmology pp. 1 - 19 |
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| Autores principales: | , , , |
| Formato: | diagnostic images pictorial tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
4/15/2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=176634605&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 176634605 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 25158414 LAW0 jtl: Therapeutic Advances in Ophthalmology issn: 25158414 maglogo: Y pubinfo: dt: 4/15/2024 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 176634605 176634605 176634605 10.1177/25158414241240687 176634605 ppf: 1 ppct: 18 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Case series of retinal vein occlusions showing early recovery using oral l -methylfolate. aug: au: Baker, Steven Baker, Dylan Baker, Robert Brown, Craig J. affil: Conceptualization, Northwest Arkansas NeuroVision, Fayetteville, AR, USA sug: subj: Retinal Vein Occlusion Surgery Retinal Vein Occlusion Drug Therapy Antidepressive Agents Administration and Dosage Administration, Oral Vitamins Therapeutic Use Retinal Vein Occlusion Diagnosis Dietary Supplementation Prescribing Patterns Visual Acuity Retina Pathology Optic Nerve Tomography, Optical Coherence Methods Polymorphism, Genetic Nutritional Status ab: This case series describes the aggregate rate of recovery in five consecutive subjects (six eyes) with retinal vein occlusion (RVO) who received l -methylfolate and other vitamins via Ocufolin®, a medical food. Subjects were followed for 10–33 months by a single ophthalmologist. Ocufolin® was prescribed at the time of diagnosis and subjects remained on the regimen throughout the time of observation. Examinations were performed in an un-masked fashion at 3-month intervals with recording of best corrected visual acuity (BCVA), average retinal nerve fiber layer (ARNFL) and central macular thickness (CMT), and fundus (examination of the retina, macula, optic nerve, and vessels) photography. Testing was done for vitamin deficiencies, vascular and coagulable risk factors, and methylenetetrahydrofolate reductase (MTHFR) polymorphisms. Vitamin deficiencies and vascular risk factors were found in all subjects, and all four tested subjects carried at least one MTHFR polymorphism. By the end of the study period BCVA in all subjects was 20/25 or better. Cystoid macular edema was identified and measured by optical coherence tomography (OCT). The percent change was calculated and plotted at 3-month intervals using the percent change in thickness from the time of diagnosis and percent change toward normative values for ARNFL and CMT. The total reduction in thickness of ARNFL and CMT from time of diagnosis was 44.19% and 30.27%, respectively. The comparison to normative data shows a reduction of ARNFL from 164.2% to 94% and CMT from 154.4% to 112.7% of normal thickness (100%). Plots showed the aggregate recovery was most rapid over the first 3 months and slowed over the next 3 months with most of the recovery taking place within 6 months of treatment. The rate of improvement in BCVA and resolution of retinal thickening was found to be better than predicted on historical grounds. No subjects progressed from nonischemic to ischemic RVO. Vitamin deficiencies, vascular risk factors, and genetic predisposition to oxidative stress were common in this RVO series. It appears that addressing these factors with Ocufolin® had a salutary effect on recovery. pubtype: Academic Journal doctype: diagnostic images pictorial tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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