Xenograft recipients and the right to withdraw from a clinical trial.
Preclinical xenotransplantation research using genetically engineered pigs has begun to show some promising results and could one day offer a scalable means of addressing organ shortage. While it is a fundamental tenet of ethical human subject research that participants have a right to withdraw from...
| Publicado en: | Bioethics Vol. 38; no. 4; pp. 308 - 316 |
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| Autores principales: | , , , |
| Formato: | Artículo |
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Wiley-Blackwell
May2024
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=176635481&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 176635481 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 02699702 6PJ jtl: Bioethics issn: 02699702 maglogo: Y pubinfo: dt: May2024 vid: 38 iid: 4 pid: 480 pub: Wiley-Blackwell artinfo: ui: 176635481 10.1111/bioe.13262 ppf: 308 ppct: 8 formats: tig: atl: Xenograft recipients and the right to withdraw from a clinical trial. aug: au: Bobier, Christopher Hurst, Daniel J. Rodger, Daniel Omelianchuk, Adam affil: Department of Theology and Philosophy, Associate Director, Hendrickson Institute for Ethical Leadership, St. Mary's University of Minnesota, Winona Minnesota,, USA Department of Family Medicine Rowan University School of Osteopathic Medicine Stratford, New Jersey,, USA Institute of Health and Social Care, School of Allied and Community Health, London South Bank University, London, UK Department of Psychological Sciences, Birkbeck, University of London, London, UK Center for Medical Ethics and Health Policy at Baylor College of Medicine, Houston Texas,, USA su: Patients Patients' rights Human research subjects Termination of treatment Clinical trials Infectious disease transmission Public health Law Legislation Disease risk factors Transplantation of organs, tissues, etc. Xenografts Zoonoses Biosurveillance sug: subj: Patients Patients' rights Human research subjects Termination of treatment Clinical trials Infectious disease transmission Public health Law Legislation Disease risk factors Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology) Health and Welfare Funds Transplantation of organs, tissues, etc. Xenografts Zoonoses Biosurveillance keyword: patient rights public health xenotransplantation zoonosis patient rights public health xenotransplantation zoonosis ab: Preclinical xenotransplantation research using genetically engineered pigs has begun to show some promising results and could one day offer a scalable means of addressing organ shortage. While it is a fundamental tenet of ethical human subject research that participants have a right to withdraw from research once enrolled, several scholars have argued that the right to withdraw from xenotransplant research should be suspended because of the public health risks posed by xenozoonotic transmission. Here, we present a comprehensive critical evaluation of the claim that xenotransplant recipients should be required to waive their right to withdraw from lifelong biosurveillance. We conclude that if xenotransplantation requires participants to waive their right to withdraw, then clinical trials may not be justifiable, given the ethical and legal obstacles involved with doing so. Consequently, if clinical trials are permitted with a right to withdraw, then they may pose a significant public health risk. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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