Association of serum uric acid with functional disability in older subjects: a population-based study.
Background: The role of serum uric acid (SUA) in the development of adverse health outcomes in advanced age is still uncertain. Aims: The aim of the study was to assess the association of disability with SUA levels in older community-dwelling subjects. Methods: We assessed the association of disabil...
| Publicado en: | Aging Clinical & Experimental Research Vol. 36; no. 1; pp. 1 - 6 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jan2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=176774237&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 176774237 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15940667 2WMP jtl: Aging Clinical & Experimental Research issn: 15940667 maglogo: N pubinfo: dt: Jan2024 vid: 36 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 176774237 10.1007/s40520-024-02746-2 176774237 ppf: 1 ppct: 5 formats: tig: atl: Association of serum uric acid with functional disability in older subjects: a population-based study. aug: au: Laudisio, Alice Dorizzi, Agnese Villeggia, Fabio Latino, Francesca Filippucci, Daniele Zuccalà, Giuseppe affil: Department of Medicine, Research Unit of Geriatrics, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21 - 00128, Roma, Italy sug: ab: Background: The role of serum uric acid (SUA) in the development of adverse health outcomes in advanced age is still uncertain. Aims: The aim of the study was to assess the association of disability with SUA levels in older community-dwelling subjects. Methods: We assessed the association of disability with SUA in all 351 inhabitants of Tuscania (Italy) aged 75+. Functional ability was estimated using the instrumental activities of daily living (IADLs). Results: In logistic regression, increasing SUA levels were associated with disability (OR = 1.22; 95%CI = 1.01–1.48; P =.036), after adjusting. The association was independent of both gender and age (P for interaction > 0.050). SUA levels above 5.5 mg/dL best predicted disability. Conclusions: In older subjects, SUA levels are associated with disability; the cut off level above 5.5 mg/dL might be adopted in pharmacological trials aiming at reducing the incidence and progression of disability by reducing SUA, and for identifying subjects at increased risk of disability. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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